Hello Freesrufer Team, 

I am trying to use the Partial volume correction procedure implemented in the freesurfer 6 beta version and have a few questions. 

In your recent Neuroimaging paper, the left and right hemispheres were combined by taking the average of the two as they did not show any age-by-hemisphere interaction.

I might have interpreted the Supplementary figure 1 incorrectly, but the Geometric transfer matrix seem to show around 52 ROI's, So were the L and R ROIs combined for the PVC results you reported in  that paper? Or were the same 52 used for the general PVC in the FS pipeline?

Do you have any concrete results to examine the effects of the size variation over the ROIs used for PVC? Should a threshold be set for the sizes of these ROIs?

How were the white matter hypo-intensities dealt with while generating the ROI masks? 

Thanks,

Pradeep