Hello,

I was wondering if someone could answer my question below

Can I use mri_glmfit-sim after mri_glmfit on the longitudinal pc1 files.

Are there any set of parameters that should be set differently when using pc1 instead of thickness files?

Thanks!

Swati

____________________________________________

Swati Rane Levendovszky, PhD

Interim Director,Diagnostic Imaging Sciences Center

Assistant Professor,Integrated Brain Imaging Center

Radiology

University of Washington

Box 357115 | AA035 HSB | Seattle, WA 98195

srleven@uw.edu | Ph: 206 543 6159
Web: https://sites.google.com/site/uwswatirane/
____________________________________________

From: <freesurfer-bounces@nmr.mgh.harvard.edu> on behalf of Swati Rane <srleven@uw.edu>
Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Date: Friday, January 10, 2020 at 10:06 AM
To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] mri_glmfit-sim for longitudinal pipelines

External Email - Use Caution

Hello FreeSurfer Developers,

I'm attempting to compare longitudinal cortical thinning rates (pc1) between 3 groups using mri_glmfit using FreeSurfer 6.0. The tutorial suggests that you could use the multiple comparisons corrections that come with it but does not comment on using the mri_glmfit-sim option.

I just want to confirm whether there is anything prohibiting me from using mri_glmfit-sim. Are there any set of parameters that should be set differently when using pc-1 instead of thickness files?

Also, would you do a stricter correction and stick to the longitudinal model or prefer the linear mixed effects model and do a FDR? How do you decide between the two?

Thanks!

Swati