ICV is fixed across time (derived from the template image), so that data can be compared directly, but for cross subject analysis you still need to adjust for ICV of course.

On 15. May 2018, at 03:19, Tamir Eisenstein <tamire1@mail.tau.ac.il> wrote:

Hello Freesurfer experts,

If I want to analyze the volume difference of regions (2 time points) after performing all the 3 steps of the longitudinal pipeline, do I need to adjust each volume in the "long" directories to its specific "tp.long" ICV or are the data of the two "long" directories already "adjusted" to the template and there is no need for the specific time-point ICV adjustment?

Thanks!
Tamir
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