I still have some concerns I would like to share. 1) Is it necessary to fill in parts of the ventricles that have not been included in yellow in the wm mask? 2) How to proceed with those little holes which do not affect the wm surface (image 1)? 3) Conversely, how to deal with little "spots" of wm mask which are frequently found in medial temporal areas (such as those in the enclosed image 2)? and 4) what surface must we take as a reference to make oll the edits, the wm or the smoothwm.nofix?