Hi FreeSurfer experts,

 

I am using the univariate LME pipeline (lme_fit_FS & lme_F) to conduct cortical thickness analysis on a subset of D-K atlas ROIs between two groups. Although I am testing longitudinal group*time differences with this pipeline, I am wondering if it is valid to test group-level differences (irrespective of time) with this model as well. I have been doing so by specifying only the group covariate in the contrast matrix before running the model.

 

 

Thank you,

Daniel Bondi