In some cases, we are seeing that, for the same subject, the run time is slower for 5.3 versus 5.2;  
A quick check on recon-all-status.log shows that the CA Reg Inv step is taking longer with 5.3.

recon-all-status.log from data processed with 5.2:

#@# CA Reg Thu Jan 17 16:03:53 PST 2013
#@# CA Reg Inv Thu Jan 17 20:17:32 PST 2013

recon-all-status.log from data processed with 5.3

#@# CA Reg Mon Jun  3 19:46:37 PDT 2013
#@# CA Reg Inv Tue Jun  4 04:52:57 PDT 2013

 Is this expected ? Or in your own testing are the recon-all processing times similar for 5.2 versus 5.3 ? The recon-all.log file for both cases are attached;
Thanks
Mehul