Dear FreeSurfers,

I am editing a paper on subcortical volumes in deficit schizophrenia after some reviewers' comments.
On of them suggested me to correct the volumes of subcortical structures for whole brain volume instead of intracranial volume. In the reviewer's opinion ICV  estimated by FreeSurfer 5.1 has a bad quality and is not reliable. However,  neither the reviewer provides any evidence, nor I could find any...
Is there any evidence for this?

Thanks in advance,

Pietro

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Pietro De Rossi, MD
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Sapienza Università di Roma, Facoltà di Medicina e Psicologia, Dipartimento NESMOS (Neuroscienze, Salute Mentale, Organi di Senso), Ospedale Sant'Andrea, Via di Grottarossa 1035-1039, 00189 Roma

NESMOS Department (Neurosciences, Mental Health and Sensory Functions), School of Medicine and Psychology, Sapienza University, Sant’Andrea Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy

Laboratorio di Neuropsichiatria, Dipartimento di Neurologia Clinica e Comportamentale, IRCCS Fondazione Santa Lucia, via Ardeatina 306 - 00179 Roma

Tel. +39 (0)6 51501358

Fax +39 (0)6 90280774

web: http://www.neuropsichiatrialab.com