Hi Dorothy

yes, we have looked at intensity effects in the gray matter before (David Salat for example has done this). It certainly reflects degree of myelination as well as other things. Which volume are you looking at? The norm should be ok for this

cheers
Bruce
On Thu, 21 Mar 2019, Dorothy Sincasto wrote:

        External Email - Use Caution        

Dear Freesurfers
Usually, the mean normalized intensity in aseg.stats is not considered important. However, by
mistake, I put it in my analysis and found out that the mean intensity of the thalamus explains a
lot the variance of my data. 

What could be the physiological meaning of higher intensity in the thalamus? Could it be associated
with either increased myelinization ( more axons or synapses) or with decreased neural soma? Has
anybody reported mean normalized intensity effects in subcortical structures?


Thanks
Dorothy

_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer