Dear FreeSurfer experts,

I would like to calculate myelin maps using the ratio between T1w and T2w scans. However, the acquisition parameters of the T2w images are slightly different (e.g. voxel size T1w = 1mm3 vs voxel size T2w = 0.35 mm3 ; T1w matrix: 240 x 240 vs T2w matrix: 640 x 640). The first step of the protocol would involve a robust registration between the two MRI images (e.g. bbregister method) which would lead to a downsampling of the T2w images. My question is, could I conduct a reliable analysis of T1w/T2w ratio maps despite these differences in the acquisition parameters between both MRI sequences?.

Thank you very much in advance.

Best regards,

Steve.