Hello All,
We are trying to obtain an accurate
measurement of the total WM volume (cerebral WM + WM hypointensities) in a
group of patients with multiple sclerosis (MS).
As per Bruce’s suggestion, we are now
using mris_wm_volume that gives more accurate measures than aseg.stats.
When looking at our data we have noticed
that within the WM surface (yellow line) there are many voxels labeled as Cerebral-Cortex (mainly in places where we
put cp to expand the WM surface),
and some others labeled as None (mainly
in places of iuxtacortical MS lesions).
As expected basing on how mris_wm_volume
works, we have noticed that WM volume actually change upon manual editing of
these mislabeled voxels in the aseg.mgz (i.e. relabeling them as actual WM).
Thus, we were wondering if there is any
way to capture and correct for all these mislabeled voxels in a more automated
manner (i.e. automatically considering Cerebral-Cortex
and None voxels included in the
WM surface as actual WM in the mris_wm_volume computation).
In this way it should be possible to get
more accurate measures of WM volumes as well as save a lot of time in manual
editing.
Thanks a lot in advance,
Antonio
Antonio Gallo, MD
NIB-NINDS-NIH
Building 10, Room 5C203B
ph #: 001-301-496.7368
fax #: 001-301-402.0373
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