Hi Douglas,

Thanks alot for your email. the issue is that when I try ti view the sig.mgh using the following command:

freeview -f $SUBJECTS_DIR/fsaverage/surf/lh.inflated:overlay=lh.disease_Healthy_Age.glmdir/lh-MS_vs_Healthy/sig.mgh:overlay_threshold=2,5 -viewport 3d

I get the attached images (please, see attached).

What are the blue and red clusters in this case? Are these the cortical regions that are statistically different between healthy and patients? or they represent the significant correlation with other variables?

What is the difference between F and sig maps?

My aim is to find/show cortical areas that are statistically different between health and patients (in terms of cortical thickness).

Many thanks in advance,
Ali

On Fri, Jun 9, 2017 at 4:45 PM, Douglas Greve <greve@nmr.mgh.harvard.edu> wrote:

Hi Ali, the FSGD and contrast matrices look right as do your command lines. What is the problem?


On 6/8/17 1:40 PM, Ali Radaideh wrote:
Dear Douglas,

Can I check with you if you have received my reply below to your question??

Thanks,
Ali


On Mon, Jun 5, 2017 at 10:16 PM Ali Radaideh <ali.radaideh@hu.edu.jo> wrote:
Thanks alot. 

Below are the commands I used in order:

mris_preproc --fsgd disease_Healthy_Age.fsgd --target fsaverage --hemi lh --meas thickness --out lh.disease_Healthy_Age.thickness.00.mgh

mri_surf2surf --hemi lh --s fsaverage --sval lh.disease_Healthy_Age.thickness.00.mgh --fwhm 10 --cortex --tval lh.disease_Healthy_Age.thickness.10.mgh


mri_glmfit --y lh.disease_Healthy_Age.thickness.10.mgh --fsgd disease_Healthy_Age.fsgd dods --C lh-MS_vs_Healthy.mtx --C lh-male_MS_vs_Healthy_Age.mtx --C lh-male_MS_vs_Healthy.mtx --C lh-female_MS_vs_Healthy_Age.mtx --C lh-female_MS_vs_Healthy.mtx --surf fsaverage lh --cortex --glmdir lh.disease_Healthy_Age.glmdir


mri_glmfit-sim --glmdir lh.disease_Healthy_Age.glmdir --cache 4 neg --cwp  0.05 --2spaces

On Mon, Jun 5, 2017 at 4:03 PM, Douglas Greve <greve@nmr.mgh.harvard.edu> wrote:

what is your mri_glmfit command?


On 6/4/17 8:10 PM, Ali Radaideh wrote:
Dear FS experts,

I am trying to analyse the cortical thickness for a group of MS patients and healthy controls. I have followed the instructions on how to perform group analysis but I am still unable to achieve what I am looking for.

I am trying to produce a significance map to show the cortical areas that are statistically different between MS and healthy controls (in terms of cortical thickness).

Would it be possible please to show you the matrix (fsgd) and contrasts files that I have used in my analysis?

Best regards and many thanks in advance,

Ali 

--
Ali M. Al-Radaideh. PhD
Head of Department of Medical Imaging
Vice Dean of the Faculty of Allied Health Sciences
The Hashemite University, 
Zarqa, Jordan
W.phone +962 5 3903333 ext.5422, 5355, 5364
Email: ali.radaideh@hu.edu.jo



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--
Ali M. Al-Radaideh. PhD
Head of Department of Medical Imaging
Vice Dean of the Faculty of Allied Health Sciences
The Hashemite University, 
Zarqa, Jordan
W.phone +962 5 3903333 ext.5422, 5355, 5364
Email: ali.radaideh@hu.edu.jo

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Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
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_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer


The information in this e-mail is intended only for the person to whom it is
addressed. If you believe this e-mail was sent to you in error and the e-mail
contains patient information, please contact the Partners Compliance HelpLine at
http://www.partners.org/complianceline . If the e-mail was sent to you in error
but does not contain patient information, please contact the sender and properly
dispose of the e-mail.




--
Ali M. Al-Radaideh. PhD
Head of Department of Medical Imaging
Vice Dean of the Faculty of Allied Health Sciences
The Hashemite University, 
Zarqa, Jordan
W.phone +962 5 3903333 ext.5422, 5355, 5364
Email: ali.radaideh@hu.edu.jo