We have added to the development version of FreeSurfer a tool to turn a clinical scan of any resolution and contrast intro a synthetic 1mm T1 MPRAGE that you can segment, register, etc with FreeSurfer (or any other tool, really). The tool has a dedicated mode for low-field Hyperfine scans (which are becoming increasingly popular) and also works to some extent with CT scans.

Early feedback on the tool is greatly appreciated.

Wiki page of SynthSR: https://surfer.nmr.mgh.harvard.edu/fswiki/SynthSR 

Link to download the development version of FreeSurfer: https://surfer.nmr.mgh.harvard.edu/pub/dist/freesurfer/dev/ 

Link to publication describing the method: https://www.sciencedirect.com/science/article/pii/S1053811921004833 

Pretty picture showing what SynthSR can do: attached.

Kind regards,

Eugenio

Juan Eugenio Iglesias