p.s. Natalie Voets at Oxford also has a study on this and might have some comments...

On Thu, 15 May 2008 rahul@nmr.mgh.harvard.edu wrote:

Hi Martin,

Not to belabor this topic but one of the major advantages in using
Freesurfer is that for an individual subject, you can ascertain what the
individual volume/thickness is of specific neuroanatomic areas.
Clinically, this information is of significant importance as you can then
detail whether atrophy in specific regions is predictive of a clinical
endpoint (e.g diagnosis of Alzheimer's disease) or how atrophy in specific
regions progresses over time (e.g. longitudinal anatomic change within a
specific individual). To the best of my knowledge, SPM/VBM only allows for
group comparisons, not indidividual subject morphometric information, and
does not allow you to either predict or longitudinally track morphometric
changes in a single individual.

Hope this helps,

Rahul
--
Rahul S. Desikan
rahul@nmr.mgh.harvard.edu

Gentlemen,

I am giving a lecture about aging brain. I only discuss freesurfer, since
that's the method we use for the brain volume and cortical thickness
assessment. There are other methods, such as VBM and SIENA potentially
providing similar information. I would appreciate if you could point me to
a
reference, which compares features of Freesurfer and VBM, or if you could
provide me your insight on what are the advantages of FreeSurfer over VBM.

I could think of the following:

1. Freesurfer allowes for the subvoxel precision of the volume estimation

2. VBM involves strong filtering in order to suppress variations of
individual
anatomies

3. ????

4. ????

5. ????


Thanks a lot in advance.

Martin
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