you can run 5.1 base and longitudinal on top of 5.0 cross sectional runs. Since you have not edited anything yet, I would however recommend to re-run the cross scectional runs with 5.1

For edits, please look at the wiki page

also there are examples in the longitudinal tutorial.

Basically : edit the cross, then edit the base, then there should be no need to edit the long.

In some cases you may get away with only editing the base.

----- Original Message -----

Sent: Thursday, April 19, 2012 12:21 AM

Subject: [Freesurfer] longitudinal analysis 5.0 or 5.1?

Dear Freesurfers:

We have a large group of subjects (for which we have two time-points) that were run through the recon-all stream using 5.0. We have done no manual editing yet.

We would like to do a longitudinal analysis of these subjects using 5.1 by comparing both time-points for each subject. Is that a possibility using 5.1?

Also, at what point should I correct for topographical defects, or make edits to the white matter or brain mask volume?

Should I edit both time-points separately first and then initiate the longitudinal analysis? If so, could I do the manual editing using 5.1?

thank you very much for your help,

cheers,

cat