This is a repeat question as either I did not see the response to the intial query (I apologise in that case!) or it was never answered.  I am planning to do a longitudinal analysis.  After I have processed the data through a longitudinal stream, should I use the LME model?  I understand it is the most highly recommended for a comprehensive analysis; however the Freesurfer webpage says it is for univariate and mass-univariate analyses only.  I would like to do a multivariate analysis. Can I still use the Matlab LME model?  If not, is there an alternative way to do this?  Any help would be appreciated!