Hello,

I'm interested in looking into the association of cortical thickness and white matter hyperintensity from a regional perspective. Specifically, I would like to create a figure that depicts in which ROIs does cortical thinning correlate significantly with increased white matter hyperintensity volume of the underlying white matter (not just the overall white matter hyperintensity). I have created binary masks of the white matter hyperintensity burden on each patient, and I was planning on projecting them into each respective cortex. However, I didn't know what the next step should be. I was thinking about the group analysis pipeline but didn't know whether it was applicable, as I don't want to just adjust for global white matter hyperintensity volume.

Thanks in advance for any help!

Best,

Panos