Dear Lorenzo,
Why not using the T1w images directly?
Cheers,
/Eugenio
--
Juan Eugenio Iglesias
http://www.jeiglesias.com
From:
Diana Lorenzo <lorenzo.diana@paraplegie.ch>
Date: Thursday, June 26, 2025 at 5:16 AM
To: freesurfer@nmr.mgh.harvard.edu <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] SynthSR - T1 3D post-gadoinium vs. T2 FSE 4mm
External Email - Use Caution
Dear All,
we are running a project on brain morphometry in a clinical sample without brain injury.
For most patients, we have both:
We would like to obtain high-resolution T1 images with SynthSR followed by standard voxel-based and surface-based processing in CAT12.
I am wondering which contrast is best suited for our purpose, also considering that our clinical sample has no brain injury and the only blood vessels are enhanced in post-gadolinium sequences.
I made some attempts on both sequences for a couple participants and segmented them with CAT12.
The overall image quality rating is almost identical. So is the estimate of total intracranial volume, with some differences in grey matter volume estimation (generally smaller in synthetized post-gado
sequences vs synthetized T2) and CSF (generally bigger in synthetized post-gado). I haven't checked surface-based metrics.
I am quite new to the field, and I really appreciate your help!
Best,
Lorenzo
Lorenzo Diana, PhD
PostDoc
Advanced Imaging Research (AIR) Group
Swiss Paraplegic Research
Guido A. Zäch Strasse 4
6207 Nottwil, Switzerland