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Hi Matt

The other variable is cortical power. Actually, we found that the ratio of thalamic mean intensity with normalized cortical gray matter volume is associated with cortical power. I was going to discard it but theoretically, it made sense, to take out the contribution of cortical gray matter and just leave the level of thalamic myelinization.

Regards
Dorothy

On Thu, Mar 21, 2019 at 6:48 PM Glasser, Matthew <glasserm@wustl.edu> wrote:

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What is the other variable?

Matt.

From: <freesurfer-bounces@nmr.mgh.harvard.edu> on behalf of Dorothy Sincasto <dsincasto@gmail.com>
Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Date: Thursday, March 21, 2019 at 8:44 PM
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] Gray matter normalized intensity

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Dear Freesurfers

Usually, the mean normalized intensity in aseg.stats is not considered important. However, by mistake, I put it in my analysis and found out that the mean intensity of the thalamus explains a lot the variance of my data. 

What could be the physiological meaning of higher intensity in the thalamus? Could it be associated with either increased myelinization ( more axons or synapses) or with decreased neural soma? Has anybody reported mean normalized intensity effects in subcortical structures?


Thanks
Dorothy

 

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