you can use mri_vol2surf to sample at different depths. If you want a simple average across cortex, then you can use --projfrac-avg .35 .65 .05
If you want to do more sophisticated weighting, then you will have to sample at each layer and then combine the files (eg, fscalc). Unless you have very small voxels, it probably will not make a difference.

On 12/18/18 4:50 AM, Matthieu Vanhoutte wrote:

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Dear experts,

Is there any advice on this point ?

Best,

Matthieu

Le mer. 12 déc. 2018 à 10:47, Matthieu Vanhoutte <matthieuvanhoutte@gmail.com> a écrit :

Dear Freesurfer's experts,

In order to have a robust PET signal projection, is it possible compute the projected PET signal as a weighted average of the PET signal intersecting with the surfaces ranging from 35 to 65% of the cortical tickness with a step t=5% ?

More weight would be given to the surfaces located near the mid distance between the pial and white surfaces as they have a higher probability to be well located within the cortex (using a normal distribution for example).

Thank you for helping.

Best,

Matthieu
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