Hi Fred,

You might be interested in SPHARM-PDM. We are using it in our lab to examine local differences in subcortical structures.

Also, FSL FIRST allows for vertex analysis of the various subcortical structures it can segment.

Kind regards,

- Charles




On 9 February 2013 10:00, Bruce Fischl <fischl@nmr.mgh.harvard.edu> wrote:
Hi Fred

we have done some of this, but the tools for doing so aren't documnted or
streamlined like recon-all. Localizing is a bit dicey as the apparent
localization may have more to do with the regularization in your 3D warping
than anything else. Martin Reuter has some interesting tools for
quantifying shape differences that you might be interested in.

cheers
Bruce



On Fri, 8 Feb 2013, Fred Sanders wrote:

> Hi All,
>
> Is there an approach within freesurfer (or related software) for
> examining surface morphology of subcortical structures?  WIth
> freesurfer I'm able to examine the total volume of various subcortical
> structures, but if my participants differ in volume of a subcortical
> structure, I can't determine where in that structure the difference is
> located.  I'd love to do a surface analysis of these structures,
> similar to what's done with the cortical surface. Is this possible?
> Thanks!
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>
>
>
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--
Charles Malpas 
Master of Psychology (Clinical Neuropsychology) / PhD Candidate
Melbourne School of Psychological Sciences & Department of Medicine (RMH)
The University of Melbourne 3010

Melbourne Brain Centre @ RMH
Neuropsychiatry Research Group 
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