Hello,<div><br></div><div>I asked a question similar to this last year when working with FS 4.3.1, and I&#39;m hoping that there is something new in FS 5 that can help.</div><div><br></div><div>I am having a problem where a lot of my subjects&#39; brains are larger than the eICV.  In FS 4.3.1, it is happening in about 70/140 subjects, and in FS 5, it is happening in about 30/140 subjects.  I checked them in tkregister2, and they look ok.  I can use the --old-etiv-only command, but then the problem is that my ICV shoots up to 1.7L, and my brain/ICV ratio drops to .65, way to low to be reasonable.  What could the reason for this be, and are there any other tricks that I could use?</div>

<div><br></div><div>Thank you,</div><div>Jeff Sadino</div>