Hi Doug,

No - this has nothing to do with thickness or volume maps. For that, we can just do ROI-wise analysis in FreeSurfer.

For VLSM, here is an example:

Let's say I have 10 lesion masks from 10 patients and 10 corresponding subject-wise cognitive deficit values i.e., one value for each subject. I would like to generate a statistical map showing the strength of the relationship between damage at any given voxel (using overlapping sections of those binary masks, maybe) and cognitive deficit across these 10 individuals with lesions. For example, the attached figure from this paper: MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://www.sciencedirect.com/science/article/pii/S2213158215300103 gives a spatial/anatomical map showing association between anatomical lesion location and language i.e., it shows what spatial location is significantly associated with language at what significance level.

Please let me know if you need any additional details.

Thanks.

On Mon, Feb 26, 2024 at 7:59 AM Douglas N. Greve <dgreve@mgh.harvard.edu> wrote:

Can you be even more specific? Operationally, what does it entail? Are you just trying to correlate, say, cognitive deficits to, say, thickenss?

On 2/25/2024 9:12 PM, Martin Juneja wrote:
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Hi Doug,

Sorry for not elaborating in my previous email.

Voxel lesion symptom mapping (VLSM) is a method to calculate symptom localization by estimating statistical relationships between damage to specific brain regions (it could be stroke lesion, tumor lesion or TBI lesion etc.) and resulting deficits (e.g., MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724038/ and MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://academic.oup.com/brain/article/137/9/2532/2848278). This method can guide the development of targeted interventions and rehabilitation strategies aimed at improving symptoms by targeting specific brain regions (or networks, if we use network lesion symptom mapping: MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724189/).
On Fri, Feb 23, 2024 at 10:27 AM Douglas N. Greve <dgreve@mgh.harvard.edu> wrote:
Sorry, don't know what VLSM is. Can you elaborate?

On 2/6/2024 3:19 PM, Martin Juneja wrote:
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Dear FreeSurfer community and experts,

I would greatly appreciate any help/response with the following.

Thanks.

---------- Forwarded message ---------
From: Martin Juneja <mj70481@gmail.com>
Date: Wed, Jan 31, 2024 at 7:51 PM
Subject: Vertex / voxel lesion symptom mapping
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>

Greetings FreeSurfer community,

I was just wondering if it's possible to perform vertex/voxel lesion symptom mapping (VLSM) using FreeSurfer? In other words, I would like to assess the impact of lesion topography (of course, heterogenous locations across patients) on neurocognitive function in brain tumor patients.

I would greatly appreciate any help/response.

Thanks!
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