Hi Doug,
I tried the partial volume correction method over the weekend and got some unexpected results. Many cortical GM regions were reported as having 0 uptake, left and right hemisphere uptake values for the same ROI were drastically different (i.e. 7 vs 150). Below is my code. Maybe I'm missing something?
mri_compute_volume_fractions register.dat bl_pet.nii subject_bl.pvf
fscalc --o subject.pet.pvf.nii bl_pet.nii div subject_bl.pvf.gm.mgz
mri_label2vol --seg aparc+aseg.mgz --reg register.dat --temp orig.mgz --o subject_bl.petlabel.nii
mri_segstats --seg aparc+aseg.mgz --sum /home/corinna/blstats/subject.pvcorr.segstats.csv --i subject_bl.petlabel.nii --ctab segments.txt
Corinna
No, that will be fine.
doug
corinna bauer wrote:
Will I need to re-register the pet to the mri?
On Fri, Jun 10, 2011 at 10:58 AM, Douglas N Greve <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> wrote:
you'll need to get a new version then. You won't need to reanalyze
your anatomicals in the new version, but you will need it to run
these programs.
doug
corinna bauer wrote:
I'm using 4.4.0
On Fri, Jun 10, 2011 at 10:44 AM, Douglas N Greve
<greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu><mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>> wrote:
which version are you using? Both should be in both 5.0 and
5.1.
doug
corinna bauer wrote:
Hi Doug,
I used the mri_compute_volume_fractions and fscalc commands
and got this error message:
mri_compute_volume_fractions: Command not found.
fscalc: Command not found.
Other FreeSurfer commands, such as mri_segstats are working
fine in the same batch script.
Corinna
On Wed, Jun 8, 2011 at 2:30 PM, Douglas N Greve
<greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>><mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>>> wrote:
corinna bauer wrote:
Alright that should work. So do I use the
pet.anat.nii
files
(from mri_vol2vol) as the input pet file to the
mri_compute_volume_fractions?
No, use the pet volume. This does everything in the
pet space.
Also, has anyone published using this pv
correction method
that you know of?
I don't know. I think this is how they do pvc in
pet, but I
really
don't know the lit.
An alternative method that I was thinking was to do
something
similar to the cortical thickness correction
Salat used and
sample on either side of the gray/white boundary
and the
gray/csf boundary and calculate the ratio. Do
you think
this
could account for the effects of pv in pet?
David's method was not for doing pvc, and I would
not use
it for pet.
doug
Corinna
On Wed, Jun 8, 2011 at 1:44 PM, Douglas N Greve
<greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
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<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>><tel:617-726-7422 <tel:617-726-7422>>>>><mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>
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<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>>>> wrote:
Actually, I think it only will affect the volume
measurement for
each structure, so that's no good. There is not a
flag to
mri_segstats that will do this. If you have a
registration
between
your native pet data and the FS anat, then
you can use
mri_compute_volume_fractions regfile.dat
pet.nii pvf
This will create pvf.{gm,wm,csf}.mgz
You can then correct the pet with something like
fscalc pet.nii div pvf.gm.mgz pet.pvf.nii
You can map the aparc+aseg into the pet space
using
mri_label2vol
(and the reg from above), then use
mri_segstats with the
files in
the native pet space.
doug
corinna bauer wrote:
Hi Doug,
I will give that a try. How will this account
for the
p.v. in
pet data? Does it remove the voxels that are
mixed tissue
classes? Does it account for partial volume
effects between
neighbouring grey matter structures?
Corinna
On Wed, Jun 8, 2011 at 1:06 PM, Douglas N
Greve
<greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>
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<mailto:greve@nmr.mgh.harvard.edu>>>
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<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>>>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>
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<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>
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<mailto:greve@nmr.mgh.harvard.edu>
<mailto:greve@nmr.mgh.harvard.edu
<mailto:greve@nmr.mgh.harvard.edu>>>>>> wrote:
Hi Corinna,
try adding --pv mri/norm.mgz
doug
corinna bauer wrote:
Hi all,
I am wondering if partial volume
is taken
into
account when
calculating average uptake values
of pet
data. I
know that
aseg.stats takes partial volume into
account and
I am
wondering if there is something
similar
in place for
pet data?
From what I gather, most people
when using
FreeSurfer
correct
for partial volume effects by
regressing out
cortical
thickness, but no basis for this
correction
method has been
provided. Any insight would be
appreciated.
n.b. to obtain the pet uptake
values I used
mri_segstats --seg
mri/aparc+aseg.mgz --sum
pet.segstats.dat --i
$petanat
--ctab
rois.txt
Thank you,
Corinna
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