Thanks so much for your answer.

Could you check if the following commands to perform ROI analysis with GLM are correct?

1. Create the table with the volumes of the hippocampal segmentation (1 command for each hemisphere - only replace lh with rh):

asegstats2table --statsfile hipposubfields.lh.T1.v21.stats

--fsgd CU_CI.fsgd \

--meas volume \

--all-segs \

--tablefile hipposubfields.lh.T1.v21.CU_CI.dat

2. GLM Analysis – DODS (1 command for each hemisphere - only replace lh with rh):

mri_glmfit \

--table hipposubfields.lh.T1.v21.CU_CI.dat \

--fsgd CU_CI.fsgd dods \

--C group.diff.CU_CI.mtx \

--glmdir hipposubfields.lh.T1.v21.CU_CI.glmdir

3. Correction for multiple comparisons – FDR:

mri_fdr --fdr .05 --pos --thfile --i contrast/lh.sig.mgh lh.mask.mgh hipposubfields.lh.T1.v21.CU_CI.mgh --no-log10p --i contrast/rh.sig.mgh rh.mask.mgh hipposubfields.rh.T1.v21.CU_CI.mgh --no-log10p

Are these commands correct?

Another question, in this type of analysis is image smoothing common? Like was done here MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://www.mail-archive.com/freesurfer@nmr.mgh.harvard.edu/msg52203.html

Thank you so much again!

Best regards,

Laura Willers de Souza

Master Student in Biochemistry

Zimmer Lab - Federal University of Rio Grande do Sul

- Porto Alegre/RS - Brazil