If you're studying thickness, I'm a fan of using mean cortical thickness as the covariate (since thickness is what you're studying).  I've posted on this in the past.

cheers,
-MH

-- 
Michael Harms, Ph.D.
-----------------------------------------------------------
Conte Center for the Neuroscience of Mental Disorders
Washington University School of Medicine
Department of Psychiatry, Box 8134
660 South Euclid Ave. Tel: 314-747-6173
St. Louis, MO  63110 Email: mharms@wustl.edu

From: <stdp82@virgilio.it>
Reply-To: <stdp82@virgilio.it>
Date: Thursday, April 4, 2013 7:21 AM
To: <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] cortical thickness normalization

Hi list,

I'm reading a lot of post on this list about cortical thickness normalization. 

I' m noting very different results on my data when I use mean thickness or ICV as nuisance factor than no factor. 

I'm confuse on this topic, could you advise the best way, please? 

Thanks,


Stefano
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