I'm wondering if it's possible to do a conjunction analysis on sMRI data in Freesurfer.  I would like to compare longitudinal results from 2 experimental training groups and 1 control, where I can examine: 1) which regions underwent structural changes in both of the experimental groups as compared to the control and 2) experimental condition-specific changes between the groups when accounting for the normal amount of change expected (the controls).  Of course, if you know of a better analysis to run to examine these questions, any feedback would be greatly appreciated. 

I have previously preprocessed the data using Freesurfer's longitudinal pipeline and I've run univariate LMEs using Freesurfer to compare each of the experimental groups to the control group separately.  Do you know if I can I use mri_concat with the --conjunct option using the .sig files from the LME analyses, given that these are structural MRI data?  I've only ever seen these analyses being done with fMRI data.

Thank you for taking the time to read this email.

Best,

Jennifer Legault