Good morning,

Thanks Doug for the answers. Quick naive question. The analyses I want to perform are on volumetric data parcellated using aseg and not surface data.

Does mri_glmfit work with the output of the asegstats2table or on voxelwise FA maps ?

Many thanks

Rito

On Fri, Jul 9, 2021 at 4:04 PM Douglas N. Greve <dgreve@mgh.harvard.edu> wrote:

On 7/9/2021 11:44 AM, Ritobrato Datta wrote:

External Email - Use Caution

Hi All,

I have the following data –

I have 205 subjects - each subject was imaged at 3 timepoints (baseline, followup 1 and followup 2)

The 205 subjects are split in two treatment arms with 100 subjects in the first one and 105 subjects in the second one.

For each timepoint, I have created FA maps in their native diffusion space.

I have also extracted the mean FA maps for 187 ROIs using mri_segstats.

For each timepoint, I have saved the results as a matrix (FA in 187 ROIs x 205 subjects) in a text file.

So I have three files for the three timepoints.

I have the age and cognitive score for each subject at each timepoint. And their gender.

I want to answer the following questions –

Do the baseline FA correlate with the corresponding cognitive score at baseline ?

This is a straight forward group analysis, so see MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://surfer.nmr.mgh.harvard.edu/fswiki/FsgdExamples (maybe the Two Groups (1 Factor, Two Levels), One Covariate)

I am interested in testing whether the FA changed significantly across the different timepoints and does that relate to the change in the cognitive score

See MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://surfer.nmr.mgh.harvard.edu/fswiki/RepeatedMeasuresAnova

Is there an effect of treatment on this change in FA across time ?

Also see MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://surfer.nmr.mgh.harvard.edu/fswiki/RepeatedMeasuresAnova
Can you please suggest what programs in freesurfer will allow me to test these questions on both voxelwise and ROI wise ?

Many thanks for your help and guidance,

Regards

Rito
_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Mass General Brigham Compliance HelpLine at MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be http://www.massgeneralbrigham.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
Please note that this e-mail is not secure (encrypted). If you do not wish to continue communication over unencrypted e-mail, please notify the sender of this message immediately. Continuing to send or respond to e-mail after receiving this message means you understand and accept this risk and wish to continue to communicate over unencrypted e-mail.

On Fri, Jul 9, 2021 at 11:44 AM Ritobrato Datta <ribrainsurf@gmail.com> wrote:

Hi All,

I have the following data –

I have 205 subjects - each subject was imaged at 3 timepoints (baseline, followup 1 and followup 2)

The 205 subjects are split in two treatment arms with 100 subjects in the first one and 105 subjects in the second one.

For each timepoint, I have created FA maps in their native diffusion space.

I have also extracted the mean FA maps for 187 ROIs using mri_segstats.

For each timepoint, I have saved the results as a matrix (FA in 187 ROIs x 205 subjects) in a text file.

So I have three files for the three timepoints.

I have the age and cognitive score for each subject at each timepoint. And their gender.

I want to answer the following questions –

Do the baseline FA correlate with the corresponding cognitive score at baseline ?

I am interested in testing whether the FA changed significantly across the different timepoints and does that relate to the change in the cognitive score

Is there an effect of treatment on this change in FA across time ?

Can you please suggest what programs in freesurfer will allow me to test these questions on both voxelwise and ROI wise ?

Many thanks for your help and guidance,

Regards

Rito