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Hi,

I am using Monte-Carlo simulations (for cortical thickness and volume - behavioral analysis) for clusterwise correction for multiple comparisons.

My results are either significant at (i) CFT < 0.001 and CWT < 0.1 (i.e., CWT = 0.07) (smoothing 12 mm) for cortical thickness-behavior analysis - with maxima at -4.3 (CFT)
or (ii) CFT < 0.05 and CWT < 0.001 (i.e., CWT = 0.0002) (smoothing 10 mm) for cortical volume-behavior - with maxima at -4.53 (CFT)

Both the clusters in (i) (lateral orbital frontal) and (ii) (rostral middle) are within the frontal cortex, but not overlapping !
Also, although maxima is at (i) -4.3 and (ii) -4.53, still the clusters do not survive recommended thresholds suggested inĀ https://www.ncbi.nlm.nih.gov/pubmed/29288131
And the FPR in this paper at strong CWT (i..e, 0.001) and liberal CFT (i..e, 0.05) is not calculated.

So I was wondering if there is any recommendation from the experts regarding these results, or none of these make sense becauseĀ I never get CFT < 0.001 and CWT < 0.05 (at-least).

Any help would be really appreciated.