You do need to take it into account, but you cannot if one group is 1.5T and the other is 3T.

Dear freesurfer experts,

I am presently trying to calculate hippocampal volume for two different study groups. One study group images (MDD) was acquired on 1.5T and the other age-matched study group (Healthy controls) on 3T MRI. On doing the statistics I have significant differences in the hippocampal volume correlating with their cognitive scores between the two study groups. Do I need to take into consideration different scanner parameters when doing the statistics? How do I go about it?

Thanks for your help.

Kind regards,

Sam 

--

Dr Sampada Sinha

​Research medical scientist (B)​

Department of Geriatric Mental Health (DGMH)

King George Medical University

Lucknow-226003

​, Uttar Pradesh​

India

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