For statistical analysis, the reviewer is right, see https://pubmed.ncbi.nlm.nih.gov/29288131
We are recommending permutation analysis, see

https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/MultipleComparisonsV6.0Perm
or
https://surfer.nmr.mgh.harvard.edu/fswiki/FsPalm

On 9/30/2020 9:23 AM, miracle ozzoude wrote:

        External Email - Use Caution        

Hello Experts,

I have a question regarding grey matter thickness map and signal to noise ratio. Does smoothing of the map increase signal to noise during surface based cortical thickness analyses? if yes or no, why? This question was asked by a reviewer in one of our manuscript because he/she thinks that one of the reasons to perform smoothing is to comply with random field theory hypotheses, when controlling for multiple testing. 

We did apply multiple comparison corrections using monte carlo simulation with cluster threshold of 2, 5000 iterations, and bonferroni. 

Thanks alot. 

best,

Paul

_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer