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Dear experts,

I would like to create myelin maps calculating the T1w/T2w ratio. Should
I apply bias field correction and intensity normalization (i.e., "nu
correction" in the Freesurfer pipeline) to T1w and T2w images separately
before calculating the T1w/T2 ratio?

I applied nu correction to T1w images and worked fine but results were
weird when nu correction was applied applied to T2w images. I am not
sure if nu correction must only be applied to T1w images for this
purpose, or if I have to modify some parameters to apply nu correction
to T2w images.

Thank you in advance for your help.

Best,
Marina

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