So you are not processing this with the longitudinal stream? You are just running each image independently through freesurfer and look at the results? 
Is there motion in all the 4 time points in this subject or only in the one image that you send? With motion artifacts, surfaces are not very reliable.

Best, martin


On Jun 28, 2013, at 11:36 AM, Jonathan Holt <whatsdac@umich.edu> wrote:

We have 4 time points for that subject and it's an issue in all 4, to a lesser degree in one of them, but still an issue. Same area, same hemisphere, every time. Perhaps it is pathology based, I am not entirely sure.



On Jun 28, 2013, at 11:19 AM, Martin Reuter wrote:

Hi Jonathan,

is this in cross sectional processing or in longitudinal?

One thing I notice is significant motion artifacts (ringing), which seem to lead to underestimation of WM, also you could fine tune the skull strip.

Best, Martin

On Jun 28, 2013, at 10:19 AM, Jonathan Holt <whatsdac@umich.edu> wrote:

Hi all,

I'm having a bit of trouble with one particular subject for which we brains for 4-5 different time points. The pial surface is consistently misplaced in the same area, see attached main/aux volume images. I'm hesitant to manually replace the white matter myself as I fear it wouldn't be as accurate. Suggestions on other methods to fix this?

The problem is always in the LH temporal right around the lateral inferior ventricle and the fusiform and other subcortical structures. 


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Dr. Martin Reuter
Assistant in Neuroscience - Massachusetts General Hospital
Instructor in Neurology   - Harvard Medical School
MGH / HMS / MIT

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Dr. Martin Reuter
Assistant in Neuroscience - Massachusetts General Hospital
Instructor in Neurology   - Harvard Medical School
MGH / HMS / MIT

A.A.Martinos Center for Biomedical Imaging
149 Thirteenth Street, Suite 2301
Charlestown, MA 02129

Phone: +1-617-724-5652
Email: