I don't know. I've never seen this type of analysis. I think with and without would be valid analyses, but they would be answering different questions, so, as the scientist doing the study, it is more up to you.

On 11/27/2020 8:56 AM, Letitia Schneider wrote:

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Dear Freesurfer team,

When I analyse the mean curvature value of a particular ROI, do I have to control for overall brain curvature, to make sure the results are not driven by individual differences in overall brain curvature?

Best wishes,

Letitia Schneider
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