Hello FreeSurfer experts,<br><br>I have been reconstructing many brains and noticed that the surfaces are quite bumpy. Here are a few things I have done to fix or understand more about the consistently bumpy surfaces I seem to generate after reconstruction:<br>

<br>1) Checked the talairach.xfm files with tkmedit and tkregister2 (it looked fine in all planes)<br>2) I have run mri_convert on original, talairach, and ac-pc aligned dicoms (Bruce, you were right, there did not appear to be any improvement from the original. Actually, the originals produced fewer surface errors).<br>

<br>I have attached four .jpg images of white matter errors (bumps) in both tksurfer and tkmedit views with the same white matter points. Can you tell me if you see any errors in tkmedit that I am missing? I dont&#39; seem to see any considerable pial/white matter inconsistencies yet continue to produce very bumpy surfaces. Also, why do some brains produce more bumps than others? I realize that a bad talairach may cause errors but my talairachs seem to be fine.<br>

<br>Thanks in advance for all of your time,<br><br>Jesse<br clear="all"><br><br>