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Some commands such as mri_synthsr in previous releases, e.g., 7.4.1, use code built with Intel processor specific instructions that cannot run on an arm processor, i.e., there is not full backwards binary compatibility in that case using the Rosetta emulation environment on MacOS..  Hence the “illegal instruction” error.

We do have a (more recent) development build on a Silicon Mac you can download via the link, 

https://surfer.nmr.mgh.harvard.edu/pub/dist/freesurfer/dev/freesurfer-macOS-darwin_arm64-dev.pkg

... it has not yet gone the the same testing as done for a release.  Please let us know if you run into issues trying it.

- R.

On May 28, 2024, at 16:08, Tabasi, Farhad <farhad-tabasi@uiowa.edu> wrote:

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Hello FreeSurfer developers,

I am trying to use mri_synthsr to improve the quality of clinical scans, but this is the error I encountered:

Illegal instruction: 4

(I followed the instructions on SynthSR page, using mri_synthsr --i input.nii --o output_synthT1.nii command)

FreeSurfer version: freesurfer-darwin-macOS-7.3.2-20220804-6354275
OS: macOS Ventura (13.2.1) on iMac M1 (116 GB)

This is likely related to binary problems or CPU compatibility (especially with M1).
Is there any solution to the issue?

Thanks,
Farhad

Farhad Tabasi, MD (he/him/his)
Postdoctoral Scholar
Human Brain Research Lab,
Department of Neurosurgery,
Carver College of Medicine, 
University of Iowa
Cell: (858)588-2779
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