Thank you for your reply.

I just wasn't expecting ("high") values in healthy subjects. Of course FS just "sees" voxels, whether it's a lesion or other thing, but I was afraid it would be some segmentation issue. I have also other MRI contrasts but I really wanted to estimate possible T1w lesion volumes.

That's why I asked for some references, and to understand the difference between "wm-hypointensities” and “non-WM-hypointensities”. Should I sum both when referring to "T1w lesion volume"?

best regards

Em 2016-02-11 17:30, Bruce Fischl escreveu:

you can turn this off with the -nowmsa flag I believe in recon-all. The 
labels are for damaged white matter and damaged gray matter, which can be 
tough to distinguish based only a T1. We have some (not-yet-distributed) 
tools that do pretty well on this if you have other contrasts like 
T2/FLAIR/PD.

cheers
Bruce

On Thu, 
11 Feb 2016, Otília wrote:

Greetings, I am wondering if there is some information regarding the meaning of “wm-hypointensities” and “non-WM-hypointensities” variables from the aseg.stats file, ie, what features are included in these variables and how FS computes them. I checked previous posts that have the same issue I have now. I find some non-zero, (some cases have “quite big”) WM-hypointensities values for healthy young brains. I find it odd. I would appreciate some additional information about these issues. Thank you! Best regards,  

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