Dear FreeSurfer experts,
I have two groups and two time points and I would like to do a correlation analysis between a variable (cognition) and the change score in cortical thickness between the two time points (time2 minus time1).
I would like to see if the correlation is different among each group, if there is an interaction with the group.
The paired-diff.fsgd file (second fsgd file) is the following:
GroupDescriptorFile 1
Title OSGM
Class Group1
Class Group2
Variables cognition
Input subject1pair Group1 0.546
Input subject1pair Group2 -0.243
...
How should it be the contrasts files to see the correlation of the variable cognition with the change score in thickness taking into account the groups? And should I use DODS or DOSS?
Using DODS:
0 0 0.5 0.5
or
0 0 1 -1
I don't understand the difference between both contrasts. I think I should use the one of "0 0 1 -1" to see whether the cognition variable correlates with change in thickness differently according to the group. Is this correct?
Using DOSS:
0 0 1
Thank you very much in advance.
Kind regards,
Agurne