Hi Oerjan,

yes, MZ twins are very similar (InfoAd: are you familiar with our BrainPrint NeuroImaging paper where we compare MZ and DZ brain shapes: http://www.sciencedirect.com/science/article/pii/S1053811915000476
http://reuter.mit.edu/blue/papers/wachinger-brainprint15/wachinger-brainprint15.pdf ).

Anyway, I doubt the longitudinal stream is going to work for this, as it is really designed for longitudinal and not across subject situations (even with MZ twins I expect differences to be too large). Even if a few cases work, there will be too many that fail.

Best, Martin

On 11/04/2015 05:13 AM, Örjan de Manzano wrote:

Dear FreeSurfers,

I'm about to analyze cortical thickness in monozygotic twins discordant for certain expertise. The within-pair similarities in brain morphology are striking (e.g. twin1 x twin2 intracranial volume correlation r=.99) and you could easily play a memory game with the images. Nonetheless, there are notable within-pair differences in gyrification etc. I'm trying to figure out if the longitudinal stream, or some version of it, might still be a viable option in this situation. The sample is fairly small and I want to do what I can to maximize sensitivity. Do any of you have experience with a similar data set or ideas/opinions/recommendations?

Best regards,

Örjan
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-- 
Martin Reuter, PhD
Assistant Professor of Radiology, Harvard Medical School
Assistant Professor of Neurology, Harvard Medical School
A.A.Martinos Center for Biomedical Imaging
Massachusetts General Hospital
Research Affiliate, CSAIL, MIT
Phone: +1-617-724-5652
Web  : http://reuter.mit.edu