[Brainmap] Wed 4/21 noon @ CNY149: Phillip Sun on Quantitative chemical exchange saturation transfer MRI and its in vivo application

Adrian KC Lee akclee at nmr.mgh.harvard.edu
Sat Apr 17 11:09:01 EDT 2010
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Wed 4/21 noon
Seminar Room 2204
149 13th St., Charlestown Navy Yard

Zhe Philip Sun, Ph.D.
Assistant Professor, Department of Radiology, Harvard Medical School

Quantitative chemical exchange saturation transfer (CEST) MRI and its  
in vivo application

Chemical exchange saturation transfer (CEST) MRI is a versatile  
imaging technique that provides a remarkably sensitive method that  
allows imaging of dilute proteins/peptides and microenvironment  
properties, in complementary to conventional relaxation and structural  
MRI. In fact, the sensitivity of CEST MRI is significantly enhanced so  
polypeptide, microenvironment pH and local temperature can be imaged,  
and remains promising for in vivo applications and ultimately,  
clinical translation. CEST MRI contrast, however, is complex. The  
experimentally obtainable CEST MRI not only varies with pH and local  
concentration of CEST agents, but also depends on parameters such as  
magnetic field strength and RF irradiation amplitude. It is important  
to note that recent progress in quantitative CEST MRI suggested that  
fundamental parameters could be derived from the apparently complex  
CEST contrast. Such development, if validated, may significantly  
advance the field of CEST MRI. Specifically, we have developed a novel  
and scalable numerical solution to describe multi-pool CEST MRI, which  
can be easily extended to simulate CEST contrast of unlimited labile  
proton groups. In addition, we modified dual 2-pool CEST model and  
elucidated the amide proton transfer (APT) MRI of ischemic stroke, and  
further optimized it for clinical translation. Moreover, iopamidol, a  
commonly used X-ray contrast agent, has been explored for ratiometric  
CEST MRI, potentially important for imaging renal pH in vivo. Topics  
including simplified numerical solution, ratiometric CEST MRI, pH- 
sensitive APT imaging of acute stroke, as well as preliminary clinical  
translation of CEST MRI will be presented.

Adrian KC Lee, ScD
Martinos Center for Biomedical Imaging
149 13th St., Suite 2301
Charlestown, MA 02129
Tel: 617-726-8791
Fax: 617-726-7422

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