[Homer-users] Diffusion approximation for small distance (3mm)

[Huppert, Ted]

George-

There are several Monte Carlo programs for radiative transport or finite element models.  For example, the homer2 download includes tMCimg, mmc, mcextreme  (cuda) codes from MGH and Qiaqian Fang's work as part of "atlasviewer".  There are also FEM models like NIRFAST from Hamid Deghani's lab at Dartmouth.  There are several other programs out there (sorry to those I left off this short list).  If you are worried about short distance, probably a RTE equation is best (vs DA) but I'm not sure how much a difference that really makes at 16mm (that is pretty far in terms of scattering lengths).

Theodore Huppert, PhD
Assistant Professor
Dept of Radiology and Bioengineering
University of Pittsburgh
huppertt at upmc.edu<mailto:huppertt at upmc.edu>

On Feb 13, 2014, at 6:40 AM, "Chun-Wei Wu (吳軍緯Gmail)" <chunwei0521 at gmail.com<mailto:chunwei0521 at gmail.com>> wrote:

Hi all:

I'm using multiple-distance frequency domain NIRS (Imagent, ISS) to measure Ua & Us in rat's cerebral cortex.
However, the semi-infinite boundary condition diffusion approximation does not work when sourse-detector separation is less than 16mm (Fantini et al., 1994).
Does any one know any updated DA model for small sourse-detector separation (frequency domain study with multiple distance: 3, 6, 9 &12 mm)?

Thanks a lot!

George
--
吳軍緯 Chun-Wei Wu (George)
Ph.D Student
Biomedical Engineering
National Cheng Kung University
No.1 University Rd., 701 Tainan, Taiwan, R.O.C.
886-6-2757575 #63431-133
E-mail: chunwei0521 at gmail.com<mailto:chunwei0521 at gmail.com>
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