[Mne_analysis] MNE source estimate analysis with multiple conditions

Lin Wang wanglinsisi at gmail.com
Wed May 31 17:02:37 EDT 2017
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Hi Eric and Alex,

Now I think understand why the sign flip affects the source-level results
within a ROI.

Thanks again, Eric! That's exactly what I want to know. So I'll morph all
subjects to the same space first, and then conduct any ROI-based
statistical analysis on the sign flipped values?

Thanks!
Lin

On Wed, May 31, 2017 at 9:56 AM, Eric Larson <larson.eric.d at gmail.com>
wrote:

> In all examples the sign flip is not data dependent.
>>
>>>
>>> Then do we need to worry about the signs when averaging across subjects?
>>> Or do I misunderstand something?
>>>
>>
> Just want to add that, although the flip does not depend on the MEG data,
> it does depend on the MRI data. Because the flip sign is arbitrary and
> subject cortical geometries vary, the effective direction and sign can
> change on a subject-by-subject basis. So one option is to morph all
> subjects to the same space (e.g., to fsaverage ico-5) and do the sign
> flipping on an identical source space. You lose some of the geometrical
> accuracy of the sign flipping, but the alignment direction and sign
> flipping should then be identical across subjects.
>
> Eric
>
>
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