[Mne_analysis] Source Modeling HCP data in MNE

[Denis-Alexander Engemann]

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Hi Matt,

The warnings only concern the fact that for the Magnes WH3600 MEG
system, reference channels can be tricky to handle and some details
can depend on the site. MNE and also the mne-hcp toolbox are not
including the reference channels in the source modeling. This is
pretty standard for certain sites (e.g. Jülich) and in my experience
has no practical impact for the results. You would have the same
gotcha when using standard MNE-code for such MEG data.
Look at the examples and conduct your own benchmarks perhaps (visual,
motor, etc.), if you are not sure.

Everything else works fine, just the the i/o is more complicated due
to the way the HCP data is shipped.

You can process inputs at different levels of processing, see here for
example source localization of preprocessed evokeds:
https://mne.tools/mne-hcp/auto_tutorials/plot_compute_evoked_inverse_solution.html#sphx-glr-auto-tutorials-plot-compute-evoked-inverse-solution-py

You should be able to do the same with preprocessed epochs (I found
reprocessing from scratch can give cleaner results though).

As to the alternatives, there is not much to do as the way HCP is
shipped does not allow for standard processing and requires a specific
choreography of transformations to use the coregistration information
with the head models and the MEG outputs.
But once more, this is not arbitrary, it's just a different way of
parsing the otherwise correct inputs.

Let me know if you have any questions and how it goes.

Best wishes,
Denis

On Mon, Sep 28, 2020 at 1:49 AM Winter, Matthew <mattwint at iu.edu> wrote:
>
>         External Email - Use Caution
>
> Hi everyone,
>
>
>
> I am trying to figure out what would be better to go towards source modeling activity with the hcp data. Should I use the hcp-mne toolbox and start from the raw instance or load in only what I need from the tmegpreproc files (preprocessed meg files) and raw files into mne? My hold back on using the hcp-mne toolbox is there is a whole 'Gotchas' sections that seems to say something about it not producing accurate source models, and it is not very clear  to me what the workarounds are if there are any. I am assuming the tmegpreproc files cannot be brought over with the hcp-mne toolbox, so if I am wrong please let me know.
>
>
>
> Best,
>
> Matt
>
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