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<body lang="FI" link="blue" vlink="purple"><p><span style="padding: 3px 10px; border-radius: 5px; color: #ffffff; font-weight: bold; display: inline-block; background-color: #ff0000;"> External Email - Use Caution </span></p><p></p>
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<p class="MsoNormal"><span lang="EN-CA" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">Thank you Alex for your fast reply! If I understood correctly, then these small values are indeed correct and should be
comparable to others obtained with the same method (e.g. for group comparisons), even if they are not the absolute amplitudes. Is that correct? What about the unit, is it indeed Am or should it rather be called an arbitrary unit?<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">Best regards,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">Anja<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif">From:</span></b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif"> mne_analysis-bounces@nmr.mgh.harvard.edu [mailto:mne_analysis-bounces@nmr.mgh.harvard.edu]
<b>On Behalf Of </b>Alexandre Gramfort<br>
<b>Sent:</b> tiistaina 8. lokakuuta 2019 11.51<br>
<b>To:</b> Discussion and support forum for the users of MNE Software <mne_analysis@nmr.mgh.harvard.edu><br>
<b>Subject:</b> Re: [Mne_analysis] weighted MNE units<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p><b><span style="color:white;background:red"> External Email - Use Caution </span></b><o:p></o:p></p>
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<p class="MsoNormal">Dear <span style="font-family:"Calibri",sans-serif;color:black">Anja,</span><o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">MNE promotes sources with minimal energy / variance. This leads</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">to a bias in the estimated amplitudes. If you care about absolute</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">amplitudes you should have a look at dipole fits or sparse solvers</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">that estimate multi-dipole configurations.</span><o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">HTH</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">Alex</span><o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">On Tue, Oct 8, 2019 at 10:15 AM Thiede, Anja <<a href="mailto:anja.thiede@helsinki.fi">anja.thiede@helsinki.fi</a>> wrote:<o:p></o:p></p>
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<p><b><span style="color:white;background:red"> External Email - Use Caution </span></b><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">Hi,<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">I am using MNE Python to do source modeling with weighted MNE and am wondering about very small units of the sources. This is something that I have found with my own data and could
reproduce the issue using the sample data: <a href="https://github.com/athiede13/speech_sources/blob/master/weighted_MNE_sample.py" target="_blank" id="gmail-m_-3638323032408062748LPlnk737906">
https://github.com/athiede13/speech_sources/blob/master/weighted_MNE_sample.py</a><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">While I would expect source activations in the range of 30-60 nAm (for example as in dipole solution
<a href="https://mne.tools/stable/auto_examples/inverse/plot_mixed_norm_inverse.html" target="_blank" id="gmail-m_-3638323032408062748LPlnk464103">
https://mne.tools/stable/auto_examples/inverse/plot_mixed_norm_inverse.html</a> that uses the same data), what I get are values in the range of 0.3-0.6 nAm. So there seems to be a difference of 2 orders of magnitude. Do you know where this could come from?
I have pondered about this for a while and cannot find the source of the difference.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">Thanks for having a look and I hope that we can figure it out!<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">Best regards,<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black">Anja Thiede<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
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<p style="margin:0cm;margin-bottom:.0001pt;background:white"><span style="font-family:"Calibri",sans-serif;color:black">_________________________________________________________________________<br>
Anja Thiede, M.Sc.<br>
Doctoral student<o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span lang="EN-US" style="font-family:"Calibri",sans-serif;color:black">Cognitive Brain Research Unit
</span><span style="font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span lang="EN-US" style="font-family:"Calibri",sans-serif;color:black">Department of Psychology and Logopedics</span><span style="font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span lang="EN-US" style="font-family:"Calibri",sans-serif;color:black">Faculty of Medicine
</span><span style="font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span lang="EN-US" style="font-family:"Calibri",sans-serif;color:black">University of Helsinki</span><span style="font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">E-Mail:
<a href="mailto:anja.thiede@helsinki.fi" target="_blank">anja.thiede@helsinki.fi</a><o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
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