[Mne_analysis] Advice on morphing

[dgw]

Yes, I think that is the best way to do it in the c-code

On Thu, Oct 8, 2015 at 10:43 AM, Scott Marek <smarek0502 at gmail.com> wrote:

> Hi all,
>
> Note: This is still Natalie, replying from a friend's account because I
> didn't get your response to my inbox yet (digest settings), but I wanted to
> ask a follow up question.
>
> I want to confirm regarding the prior: when I have the group-level fMRI
> prior in fsaverage space as a .w file, I should morph that to each
> individual subject's space for use in mne_do_inverse_operator, correct?
> (Using mri_surf2surf for instance...)
>
> I will then define labels on the fsaverage fMRI map and morph the labels
> to each individual to when I want to extract source estimates for the
> labels.
>
> Thank you,
>
> Natalie
>
> On Thu, Oct 8, 2015 at 10:00 AM, dgw <dgwakeman at gmail.com> wrote:
>
>> Hi Natalie,
>>
>> IMO
>> a modified version of option 1 is the best option. Morph the labels to
>> the individual's space.
>>
>> Then, instead of morphing the later inverse solutions back to
>> fsaverage, simply extract the data only from the group defined labels
>> and run stats on the label data only. This strategy reduces the amount
>> of morphing and fits your hypothesis that the fMRI labels contain the
>> activity of interest (which the strong fMRI prior will make happen
>> anyway). The subsequent morphing would not accomplish anything (except
>> possibly introduce erroneous smoothing), because the labels are
>> derived from the average space anyway, so each label is equivalent in
>> the different participants.
>>
>> hth
>> d
>>
>> On Thu, Oct 8, 2015 at 9:09 AM, Natalie Klein <neklein at andrew.cmu.edu>
>> wrote:
>> > Hello,
>> >
>> > I want to use a group-level fMRI map (in fsaverage space) as an fMRI
>> prior
>> > for MNE source localization. I also want to define labels from the fMRI
>> map
>> > that can be used for all subjects.
>> >
>> > Previously, I created source spaces for all subjects in each one's
>> > individual anatomical space. I could not find any tools that allow me to
>> > morph these source spaces to fsaverage before doing forward/inverse
>> solution
>> > - it seems most morphing procedures are designed to be applied after the
>> > inverse solution. So it seems my options are:
>> >
>> > 1. Use the individual source spaces for the forward solution. Morph the
>> fMRI
>> > prior to each subject's individual space to do the inverse solutions.
>> Define
>> > labels on group fMRI map and then morph labels to each individual space
>> for
>> > analysis (or tediously draw labels on each morphed fMRI prior map).
>> >
>> > or
>> >
>> > 2. Redo the source spaces: morph all subjects to fsaverage space with
>> > mne_setup_source_space and perform forward/inverse solution and all
>> > remaining analysis in fsaverage space.
>> >
>> > Any advice or opinions on the best way to proceed? Option 2 seems best
>> as
>> > there is less morphing overall, but I would appreciate input/advice.
>> >
>> > Thank you,
>> >
>> > Natalie
>> >
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