Hi Cheol,
> I am using freesurfer for patients with various neural disease. I wonder the
> the
> freesurfer atlas is applicable to them: dementia (with Lewy bodies, DLB),
> epilepsy, schizophrenia, ADHD, Alzheimer, stroke. (I know some studies
> already
> used freesurfer for some of the diseases in the list,) I believe epilepsy
> patients with lobectomy cannot be applicable.
If the malformation or the difference between normal control acquisitions
and your scans is significant the FS pipeline, using the FS atlas is not
going to be successful. Withuot seeing your data I cannot tell which
population from the above is going to be affected, but if in doubt just
try processing one or two representative samples from the different
populations and assess how successful the processing is.
> Also is there age limit for the freesurfer atlas? How young can the atlas
> work
> for? 4 year-old? 6 year-old? or more than 10 year-old? How about the upper
> bound? 80 year-old?
The lower bound, in our experience, is about 4-5 yrs. Of course, it
depends on your data quality but we had success all the way down to that
age. I am not aware of any upper limits. Again, if you are processing
these kind of "extreme" populations, make sure that you inspect the
outcome of the FS recon pipeline carefully before proceeding with any
type of analysis.
Lilla