Hi all,
If I understand correctly, the surface-based morphometry (SBM) done by
Freesurfer offers superior registration as compared to voxel-based methods
such as VBM, in that:
1. "SBM smoothing respects anatomical boundaries better than the 3D VBM
smoothing".
2. "SBM group analysis employs inter-subject alignment based on the
patterns of sulci and gyri, as opposed to Talairach registration, which
often ignores sulcal/gyral landmarks"
I'm not sure I understand those reasons, however. For 1., why does the
smoothing operation (basically, a multiplication) "care" about anatomy or
registration at all, such that it can be said it is better done in SBM vs
VBM?
And for 2., doesn't the Talairach registration used in VBM simply imply a
certain target template? Surely such a template is used in SBM registration
as well, and if that is the case, then how are sulcal/gyral landmarks taken
into account?
Thanks for any help!
Tudor