Dear FreeSurfer Experts,
I want to compare structural measures(eg. thickness) between patients
and controls controling for the effects of age, gender and scanner
(parts of sample were scanned in scanner 1 parts in scanner 2).
I want to answer the question: *do patients and controls differ
significantly in lGI when controlling for age (continous variable),
gender(male/female), scanner(scanner1/scanner2)?*
*so i have to categorical (gender, scanner) and one continous variable
to control for.*
*my FSGD file looks like:*
/GroupDescriptorFile 1 //
//Class PatientFemaleScanner1//
//Class PatientFemaleScanner2//
//Class PatientMaleScanner1//
//Class PatientMaleScanner2//
//Class ControlFemaleScanner1//
//Class ControlFemaleScanner2//
//Class ControlMaleScanner1//
//Class ControlMaleScanner2//
//Variables Age //
//Input subject1 ControlMaleScanner1 23.6//
//Input subject2 ControlFemaleScanner2 37.7//
//Input subject3 PatientFemaleScanner1 32.6/
...
*Total I would have 16 regressors with following contrasts:
*
*first conrast:* is there a difference in structural measure(eg.
thickness) between *patients and controls* controlling for gender,
scanner, age?
0.25 0.25 0.25 0.25 -0.25 -0.25 -0.25 -0.25 0 0 0 0 0 0 0 0
*second contrast:* is there a difference between the two scanners
*scanner 1 and 2* controlling for effects of gender, age and group?
0.25 -0.25 0.25 -0.25 0.25 -0.25 0.25 -0.25 0 0 0 0 0 0 0 0
*Questions:*
* Are the Contrasts created ok?
* How could I control better for the effect of scanner, as part of the
sample was scanned with scanner 1 another part with scanner 2?
Thank you very much for your help!
Geo
--
Oana Georgiana Rus
PhD Student
Neuroimaging Center TUM-NIC
Klinikum rechts der Isar
Technische Universität München
Einsteinstr.1
81675 München
Raum 5.8
Tel. 089 4140 7971