Freesurfer September 2020

freesurfer@nmr.mgh.harvard.edu

111 participants
165 discussions

mean gyrification index
by vittal korann 10 Sep '20

10 Sep '20

External Email - Use Caution Thank you so much, Douglas. Could you please guide me to obtain the global mean gyrification index for each subject? With regards korann

3 16

big difference between ICV same patient....
by Gonzalo Rojas Costa 10 Sep '20

10 Sep '20

External Email - Use Caution Hi: Why I got a big ICV difference between MPRAGE of the same patient (2019: 1775887.317631, 2020: 1566398.53576 mm3), one-year difference acquisition, and the same MRI Skyra 3T equipment? I used freesurfer 5.1.0 on the same computer, and operating system in both cases... I reviewed the coregistration to MNI305 and it is reasonably good in both cases... The case was reviewed by an expert neuroradiologist, and she does not consider that there is a significant visual difference between both sizes. Sincerely Gonzalo Rojas Costa

2 1

mri_cvs_register with sub-millimeter recons
by Noriana Jakopin 10 Sep '20

10 Sep '20

External Email - Use Caution Hello Freesurfer Experts, I have been trying to run mri_cvs_register to bring sub-millimeter data into MNI space, however the final outputs have large deformations to the brain. I have tried with both 0.5 mm and 0.7 mm using their respective sub-milimeter recons. It seems that the issue arises during Step 3(i) as the el_reg_tocvs_avg35_inMNI152.mgz does not have the deformations, but the step1_CVSmorphed_tocvs_avg35_inMNI152_norm.mgz file does. Does anyone have any guidance on how I can troubleshoot this? I have attached the recon-all.log file for the 0.7 mm data. If you need me to share any other files, let me know. FreeSurfer Version: freesurfer-linux-centos6_x86_64-7.1.1 Platform: Windows Subsystem for Linux - Ubuntu 18.04 LTS Thank you, Noriana Jakopin

2 2

job opening: MRI Senior Research Specialist at Ohio State University
by Xiangrui Li 10 Sep '20

10 Sep '20

External Email - Use Caution Sorry if cross-posted. See the attachment for the job detail. Thanks. _____________ Xiangrui Li, Ph.D. Center for Cognitive and Behavioral Brain Imaging The Ohio State University Phone: 614-292-1847

1 0

tksurfer 64bit update?
by Jesse Gomez 10 Sep '20

10 Sep '20

External Email - Use Caution Hello, I noticed tksurfer disappeared in the new 7.1 version of freesurfer. While it's still present in older versions of course, it no longer runs on 64-bit only operating systems (e.g. OSX Catalina). Is tksurfer going to be updated? It seems to be the only way to draw labels and ROIs on a surface. Is there an alternative? Freeview, as far as I can tell, only has volume-based ROI-drawing methods. This surface label feature in tksurfer was fairly critical for many analyses; I do hope it's on its way back. All the best, Jesse

2 4

Re: [Freesurfer] vol2surf: lesion overlap across group into surfaces
by Horn, Mitchell Jacob 10 Sep '20

10 Sep '20

Thanks so much Douglas. Many of the lesions are in the white matter, and many span across WM and GM. In the case where the lesions on not strictly cortical, is this surface mapping not possible? Or perhaps a representative surface map showing the occurrences of lesions in any lobe/ROI? Best, Mitch

1 0

longitudinal MRI and DTI registration
by Zeng, Qi 10 Sep '20

10 Sep '20

External Email - Use Caution Hi, I was conducting a longitudinal DTI analysis. However, MRI and DTI brain scans were scheduled at different time frames. Should I be concerned that for example MRI was taken at 9/1/2006 and nearby DTI was taken on 10/1/2007 or 10/1/2009, which may result in misregistration of DTI given MRI morphology. Best, Qi

2 1

vol2surf: lesion overlap across group into surfaces
by Horn, Mitchell Jacob 10 Sep '20

10 Sep '20

Dear FS Experts, I would like to show the distribution and overlap of lesions on an average inflated brain surface as a heat map. I have a 150 subjects of which I’ve made masks of T2 lesions and moved into their respective subject-T1w-spaces (using T1.mgz as reference) where I have completed recons. What are the steps in bringing these subject-T1w-space lesions into an average brain and presenting them as a surface? Again, I hope to show the lesion distribution scaled by the number of times (out of 50 subjects) that any voxel is a lesion. Thanks in advance, Mitch

2 1

Re: [Freesurfer] Hippocampal subfields error
by Iglesias Gonzalez, Juan E. 09 Sep '20

09 Sep '20

Hi Emily. Is it possibly that you may be mixing FS versions, by any chance? Cheers, /Eugenio Juan Eugenio Iglesias Senior research fellow CMIC (UCL), MGH (HMS) and CSAIL (MIT) http://www.jeiglesias.com From: <freesurfer-bounces(a)nmr.mgh.harvard.edu> on behalf of Emily K Clarke <ekc23(a)duke.edu> Reply-To: Freesurfer support list <freesurfer(a)nmr.mgh.harvard.edu> Date: Wednesday, September 9, 2020 at 15:53 To: "freesurfer(a)nmr.mgh.harvard.edu" <freesurfer(a)nmr.mgh.harvard.edu> Subject: [Freesurfer] Hippocampal subfields error External Email - Use Caution Hi Eugenio, We’re still running into the issue where running recon-all with the hippocampal subfields tag isn’t actually generating any of the hippocampal files. I’ve included our full recon-all log below. We already examined the scans, and they look perfectly normal – do you know why this might be happening? Thanks, Emily Clarke-Rubright Morey Neuroimaging Lab The whole log message: #-------------------------------------------- #@# Hippocampal Subfields processing (T1 only) left Mon Aug 10 18:54:21 EDT 2020 ------------------------------------------ Setting up environment variables --- LD_LIBRARY_PATH is .:/usr/local/packages/freesurfer_v6.0.0/MCRv80/runtime/glnxa64:/usr/local/packages/freesurfer_v6.0.0/MCRv80/bin/glnxa64:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/os/glnxa64:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64/native_threads:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64/server:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64/client:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64:/usr/lib64/qt5/plugins/platforms:/usr/local/packages/ants-2.3.4/lib:/usr/lib64/openmpi/lib: Warning: application is running on a locale different from the original platform locale. Warning: No display specified. You will not be able to display graphics on the screen. Registering imageDump.mgz to hippocampal mask from ASEG This file does not contain MRI parameters $Id: mri_robust_register.cpp,v 1.77 2016/01/20 23:36:17 greve Exp $ --mov: Using imageDump.mgz as movable/source volume. --dst: Using /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… as target volume. --lta: Output transform as trash.lta . --mapmovhdr: Will save header adjusted movable as imageDump_coregistered.mgz ! --sat: Using saturation 50 in M-estimator! reading source 'imageDump.mgz'... reading target '/mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/…'. .. Registration::setSourceAndTarget(MRI s, MRI t, keeptype = TRUE ) Type Source : 0 Type Target : 3 ensure both FLOAT (3) Reordering axes in mov to better fit dst... ( -1 3 -2 ) MRIreorder() ----------- xdim=-1 ydim=3 zdim=-2 src 131 241 99, 0.250000 0.250000 0.250000 dst 131 99 241, 0.250000 0.250000 0.250000 Determinant after swap : 0.015625 Mov: (0.25, 0.25, 0.25)mm and dim (131, 99, 241) Dst: (1, 1, 1)mm and dim (38, 40, 59) Asserting both images: 1mm isotropic - reslicing Mov ... -- changing data type from 0 to 3 (noscale = 0)... -- Original : (0.25, 0.25, 0.25)mm and (131, 99, 241) voxels. -- Resampled: (1, 1, 1)mm and (38, 40, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 - reslicing Dst ... -- Original : (1, 1, 1)mm and (38, 40, 59) voxels. -- Resampled: (1, 1, 1)mm and (38, 40, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 Registration::computeMultiresRegistration - computing centroids - computing initial transform -- using translation info - Get Gaussian Pyramid Limits ( min size: 16 max size: -1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - initial transform: Ti = [ ... 1.0000000000000 0 0 1.1459029727155 0 1.0000000000000 0 -0.0876360601093 0 0 1.0000000000000 -2.9034875996918 0 0 0 1.0000000000000 ] - initial iscale: Ii =1 Resolution: 1 S( 19 20 30 ) T( 19 20 30 ) Iteration(f): 1 -- diff. to prev. transform: 7.11234 Iteration(f): 2 -- diff. to prev. transform: 5.92976 Iteration(f): 3 -- diff. to prev. transform: 7.00993 Iteration(f): 4 -- diff. to prev. transform: 4.91305 Iteration(f): 5 -- diff. to prev. transform: 0.781018 max it: 5 reached! Resolution: 0 S( 38 40 61 ) T( 38 40 61 ) Iteration(f): 1 -- diff. to prev. transform: 8.1296 Iteration(f): 2 -- diff. to prev. transform: 1.32542 Iteration(f): 3 -- diff. to prev. transform: 0.660013 Iteration(f): 4 -- diff. to prev. transform: 0.272219 Iteration(f): 5 -- diff. to prev. transform: 0.0943126 max it: 5 reached! - final transform: Tf = [ ... 0.9986737402682 -0.0371977207162 0.0355962086772 0.4749903609000 0.0194355513105 0.9126027300469 0.4083852549446 -14.0571487737101 -0.0476761978762 -0.4071517980857 0.9121153400046 9.9144950322154 0 0 0 1.0000000000000 ] - final iscale: If = 1 ********************************************************** * * WARNING: Registration did not converge in 5 steps! * Problem might be ill posed. * Please inspect output manually! * ********************************************************** Final Transform: Adjusting final transform due to initial resampling (voxel or size changes) ... M = [ ... -0.2496684350671 0.0088990521693 0.0092994301791 34.3717771918614 -0.0048588878276 0.1020963137361 -0.2281506825117 16.0960341057205 0.0119190494690 0.2280288350011 0.1017879495214 -5.4978401025085 0 0 0 1.0000000000000 ] Determinant : -0.015625 writing output transformation to trash.lta ... converting VOX to RAS and saving RAS2RAS... mapmovhdr: Changing vox2ras MOV header (to map to DST) ... To check aligned result, run: freeview -v /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… imageDump_coregistered.mgz Registration took 0 minutes and 1 seconds. Thank you for using RobustRegister! If you find it useful and use it for a publication, please cite: Highly Accurate Inverse Consistent Registration: A Robust Approach M. Reuter, H.D. Rosas, B. Fischl. NeuroImage 53(4):1181-1196, 2010. http://dx.doi.org/10.1016/j.neuroimage.2010.07.020 http://reuter.mit.edu/papers/reuter-robreg10.pdf $Id: mri_robust_register.cpp,v 1.77 2016/01/20 23:36:17 greve Exp $ --mov: Using imageDump.mgz as movable/source volume. --dst: Using /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… as target volume. --lta: Output transform as trash.lta . --mapmovhdr: Will save header adjusted movable as imageDump_coregistered.mgz ! --affine: Enableing affine transform! --sat: Using saturation 50 in M-estimator! reading source 'imageDump.mgz'... reading target '/mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/…'. .. Registration::setSourceAndTarget(MRI s, MRI t, keeptype = TRUE ) Type Source : 0 Type Target : 3 ensure both FLOAT (3) Reordering axes in mov to better fit dst... ( -1 3 -2 ) MRIreorder() ----------- xdim=-1 ydim=3 zdim=-2 src 131 241 99, 0.250000 0.250000 0.250000 dst 131 99 241, 0.250000 0.250000 0.250000 Determinant after swap : 0.015625 Mov: (0.25, 0.25, 0.25)mm and dim (131, 99, 241) Dst: (1, 1, 1)mm and dim (38, 40, 59) Asserting both images: 1mm isotropic - reslicing Mov ... -- changing data type from 0 to 3 (noscale = 0)... -- Original : (0.25, 0.25, 0.25)mm and (131, 99, 241) voxels. -- Resampled: (1, 1, 1)mm and (38, 40, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 - reslicing Dst ... -- Original : (1, 1, 1)mm and (38, 40, 59) voxels. -- Resampled: (1, 1, 1)mm and (38, 40, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 Registration::computeMultiresRegistration - computing centroids - computing initial transform -- using translation info - Get Gaussian Pyramid Limits ( min size: 16 max size: -1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - initial transform: Ti = [ ... 1.0000000000000 0 0 1.1459028059189 0 1.0000000000000 0 -0.0876339827813 0 0 1.0000000000000 -2.9034861096682 0 0 0 1.0000000000000 ] - initial iscale: Ii =1 Resolution: 1 S( 19 20 30 ) T( 19 20 30 ) Iteration(f): 1 -- diff. to prev. transform: 7.39891 Iteration(f): 2 -- diff. to prev. transform: 6.07128 Iteration(f): 3 -- diff. to prev. transform: 6.45354 Iteration(f): 4 -- diff. to prev. transform: 9.61165 Iteration(f): 5 -- diff. to prev. transform: 6.45157 max it: 5 reached! Resolution: 0 S( 38 40 61 ) T( 38 40 61 ) Iteration(f): 1 -- diff. to prev. transform: 18.1397 Iteration(f): 2 -- diff. to prev. transform: 10.4781 Iteration(f): 3 -- diff. to prev. transform: 4.71708 Iteration(f): 4 -- diff. to prev. transform: 2.16703 Iteration(f): 5 -- diff. to prev. transform: 0.732237 max it: 5 reached! - final transform: Tf = [ ... 1.1003251237945 0.4596695415609 0.1319823678432 -15.3375075204562 -0.0809129505733 1.0958357713115 0.4294815397408 -16.7169936140805 -0.0871431123400 -0.3796938017010 0.9044729973197 10.3182069614882 0 0 0 1.0000000000000 ] - final iscale: If = 1 ********************************************************** * * WARNING: Registration did not converge in 5 steps! * Problem might be ill posed. * Please inspect output manually! * ********************************************************** Final Transform: Adjusting final transform due to initial resampling (voxel or size changes) ... M = [ ... -0.2750812479116 0.0329955927294 -0.1149173912565 38.1277797083535 0.0202282358422 0.1073703848787 -0.2739589559572 15.8057165631404 0.0217857755217 0.2261182492690 0.0949234628220 -5.6011779490725 0 0 0 1.0000000000000 ] Determinant : -0.0203612 Decompose into Rot * Shear * Scale : Rot = [ ... -0.9711353975406 0.1063152910440 -0.2135254048909 0.2376286779964 0.3535137619413 -0.9047434064484 0.0207038894236 0.9293681073764 0.3685732898005 ] Shear = [ ... 1.0000000000000 -0.0073421724799 0.1576683162397 -0.0067818833526 1.0000000000000 -0.0678198022274 0.1779196232492 -0.0828533754661 1.0000000000000 ] Scale = diag([ 0.2723989962754 0.2516119340902 0.3073865945084 ]) writing output transformation to trash.lta ... converting VOX to RAS and saving RAS2RAS... mapmovhdr: Changing vox2ras MOV header (to map to DST) ... To check aligned result, run: freeview -v /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… imageDump_coregistered.mgz Registration took 0 minutes and 1 seconds. Thank you for using RobustRegister! If you find it useful and use it for a publication, please cite: Highly Accurate Inverse Consistent Registration: A Robust Approach M. Reuter, H.D. Rosas, B. Fischl. NeuroImage 53(4):1181-1196, 2010. http://dx.doi.org/10.1016/j.neuroimage.2010.07.020 http://reuter.mit.edu/papers/reuter-robreg10.pdf Reading contexts of file /usr/local/packages/freesurfer_v6.0.0/average/HippoSF/atlas/compressionLookupTable.txt Constructing image-to-world transform from header information (asegMod.mgz) Returning the following transform: AffineTransform (0x2b5e6a48e220) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 422 Debug: Off Object Name: Observers: none Matrix: -1 -1.86265e-09 1.3024e-09 -3.49428e-09 -1.16415e-10 1 1.86265e-09 -1 -1.16415e-10 Offset: [132.04, -111.801, 144.75] Center: [0, 0, 0] Translation: [132.04, -111.801, 144.75] Inverse: -1 1.3024e-09 1.86265e-09 -1.86265e-09 -1.16415e-10 -1 -3.49428e-09 1 -1.16415e-10 Singular: 0 Constructing image-to-world transform from header information (/mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… ) Returning the following transform: AffineTransform (0x2b5e6a48e220) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 579 Debug: Off Object Name: Observers: none Matrix: 0.275081 -0.0329956 0.114917 0.0217858 0.226118 0.0949235 -0.0202282 -0.10737 0.273959 Offset: [-38.0874, -33.402, 1.94475] Center: [0, 0, 0] Translation: [-38.0874, -33.402, 1.94475] Inverse: 3.54297 -0.162038 -1.43002 -0.38743 3.81537 -1.15946 0.109759 1.48336 3.09018 Singular: 0 Transform before cropping: AffineTransform (0x2b5e6a48e220) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 581 Debug: Off Object Name: Observers: none Matrix: -0.275081 0.0329956 -0.114917 0.0202282 0.10737 -0.273959 0.0217858 0.226118 0.0949235 Offset: [170.128, 142.806, 78.3988] Center: [0, 0, 0] Translation: [170.128, 142.806, 78.3988] Inverse: -3.54297 1.43002 -0.162038 0.38743 1.15946 3.81537 -0.109759 -3.09018 1.48336 Singular: 0 WorldToImageTransform before cropping: AffineTransform (0x2b5e6a47e8f0) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 583 Debug: Off Object Name: Observers: none Matrix: -1 1.3024e-09 1.86265e-09 -1.86265e-09 -1.16415e-10 -1 -3.49428e-09 1 -1.16415e-10 Offset: [132.04, 144.75, 111.801] Center: [0, 0, 0] Translation: [132.04, 144.75, 111.801] Inverse: -1 -1.86265e-09 1.3024e-09 -3.49428e-09 -1.16415e-10 1 1.86265e-09 -1 -1.16415e-10 Singular: 0 m_BoundingBoxSize: [131, 241,99] minimalMappedCoordinate: [123.105, 115.958,78.3988] maximalMappedCoordinate: [178.047, 171.204,144.802] Cropping with min [118 110 72] and max [184 177 151] m_OriginalImageRegion before checking margins: ImageRegion (0x2b5e69a829b8) Dimension: 3 Index: [118, 110, 72] Size: [67, 68, 80] m_CroppedImageRegion before checking margins: ImageRegion (0x2b5e69a82980) Dimension: 3 Index: [0, 0, 0] Size: [67, 68, 80] m_OriginalImageRegion after checking margins: ImageRegion (0x2b5e69a829b8) Dimension: 3 Index: [118, 110, 72] Size: [67, 68, 80] m_CroppedImageRegion after checking margins: ImageRegion (0x2b5e69a82980) Dimension: 3 Index: [0, 0, 0] Size: [67, 68, 80] Transform after cropping: AffineTransform (0x2b5e6a48e220) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 740 Debug: Off Object Name: Observers: none Matrix: -0.275081 0.0329956 -0.114917 0.0202282 0.10737 -0.273959 0.0217858 0.226118 0.0949235 Offset: [52.1278, 32.8057, 6.39882] Center: [0, 0, 0] Translation: [52.1278, 32.8057, 6.39882] Inverse: -3.54297 1.43002 -0.162038 0.38743 1.15946 3.81537 -0.109759 -3.09018 1.48336 Singular: 0 WorldToImageTransform after cropping: AffineTransform (0x2b5e6a47e8f0) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 741 Debug: Off Object Name: Observers: none Matrix: -1 1.3024e-09 1.86265e-09 -1.86265e-09 -1.16415e-10 -1 -3.49428e-09 1 -1.16415e-10 Offset: [14.0404, 34.7505, 39.8009] Center: [0, 0, 0] Translation: [14.0404, 34.7505, 39.8009] Inverse: -1 -1.86265e-09 1.3024e-09 -3.49428e-09 -1.16415e-10 1 1.86265e-09 -1 -1.16415e-10 Singular: 0 Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Careful here: the applied transformation will turn positive tetrahedra into negative ones. -0.275081 0.0329956 -0.114917 0.0202282 0.10737 -0.273959 0.0217858 0.226118 0.0949235 determinant: -0.0203612 Starting to swap the point assignments of each tetrahedron... Warning: This concatenation operation includes an empty array with an incorrect number of rows. Concatenation including empty arrays will require all arrays to have the same number of rows in a future release. [ > In segmentSubjectT1_autoEstimateAlveusML at 325] Reading contexts of file /usr/local/packages/freesurfer_v6.0.0/average/HippoSF/atlas/compressionLookupTable.txt -------------- Making Lateral-nucleus map to reduced label 1 Making Paralaminar-nucleus map to reduced label 1 Making Basal-nucleus map to reduced label 1 Making Accessory-Basal-nucleus map to reduced label 1 Making Corticoamygdaloid-transitio map to reduced label 1 Making Central-nucleus map to reduced label 1 Making Cortical-nucleus map to reduced label 1 Making Medial-nucleus map to reduced label 1 Making Anterior-amygdaloid-area-AAA map to reduced label 1 -------------- Making alveus map to reduced label 2 Making Hippocampal_tail map to reduced label 2 Making HATA map to reduced label 2 Making fimbria map to reduced label 2 Making parasubiculum map to reduced label 2 Making hippocampal-fissure map to reduced label 2 -------------- Making Left-Cerebral-Cortex map to reduced label 3 -------------- Making Left-Cerebral-White-Matter map to reduced label 4 -------------- Making Left-Lateral-Ventricle map to reduced label 5 -------------- Making Left-choroid-plexus map to reduced label 6 -------------- Making Unknown map to reduced label 7 -------------- Making Left-VentralDC map to reduced label 8 -------------- Making Left-Putamen map to reduced label 9 -------------- Making Left-Pallidum map to reduced label 10 -------------- Making Left-Thalamus-Proper map to reduced label 11 -------------- Making Left-Accumbens-area map to reduced label 12 -------------- Making Left-Caudate map to reduced label 13 Error using segmentSubjectT1_autoEstimateAlveusML (line 348) The vector of prior probabilities in the mesh nodes must always sum to one over all classes #-------------------------------------------- #@# Hippocampal Subfields processing (T1 only) right Mon Aug 10 18:54:37 EDT 2020 ------------------------------------------ Setting up environment variables --- LD_LIBRARY_PATH is .:/usr/local/packages/freesurfer_v6.0.0/MCRv80/runtime/glnxa64:/usr/local/packages/freesurfer_v6.0.0/MCRv80/bin/glnxa64:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/os/glnxa64:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64/native_threads:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64/server:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64/client:/usr/local/packages/freesurfer_v6.0.0/MCRv80/sys/java/jre/glnxa64/jre/lib/amd64:/usr/lib64/qt5/plugins/platforms:/usr/local/packages/ants-2.3.4/lib:/usr/lib64/openmpi/lib: Warning: application is running on a locale different from the original platform locale. Warning: No display specified. You will not be able to display graphics on the screen. Registering imageDump.mgz to hippocampal mask from ASEG This file does not contain MRI parameters $Id: mri_robust_register.cpp,v 1.77 2016/01/20 23:36:17 greve Exp $ --mov: Using imageDump.mgz as movable/source volume. --dst: Using /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… as target volume. --lta: Output transform as trash.lta . --mapmovhdr: Will save header adjusted movable as imageDump_coregistered.mgz ! --sat: Using saturation 50 in M-estimator! reading source 'imageDump.mgz'... reading target '/mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/…'. .. Registration::setSourceAndTarget(MRI s, MRI t, keeptype = TRUE ) Type Source : 4 Type Target : 3 ensure both FLOAT (3) Reordering axes in mov to better fit dst... ( 1 3 -2 ) MRIreorder() ----------- xdim=1 ydim=3 zdim=-2 src 131 241 99, 0.250000 0.250000 0.250000 dst 131 99 241, 0.250000 0.250000 0.250000 Determinant after swap : 0.015625 Mov: (0.25, 0.25, 0.25)mm and dim (131, 99, 241) Dst: (1, 1, 1)mm and dim (38, 43, 57) Asserting both images: 1mm isotropic - reslicing Mov ... -- changing data type from 4 to 3 (noscale = 0)... -- Original : (0.25, 0.25, 0.25)mm and (131, 99, 241) voxels. -- Resampled: (1, 1, 1)mm and (38, 43, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 - reslicing Dst ... -- Original : (1, 1, 1)mm and (38, 43, 57) voxels. -- Resampled: (1, 1, 1)mm and (38, 43, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 Registration::computeMultiresRegistration - computing centroids - computing initial transform -- using translation info - Get Gaussian Pyramid Limits ( min size: 16 max size: -1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - initial transform: Ti = [ ... 1.0000000000000 0 0 0.1781192630761 0 1.0000000000000 0 1.0539982530706 0 0 1.0000000000000 -3.1974090629449 0 0 0 1.0000000000000 ] - initial iscale: Ii =1 Resolution: 1 S( 19 21 30 ) T( 19 21 30 ) Iteration(f): 1 -- diff. to prev. transform: 13.2959 Iteration(f): 2 -- diff. to prev. transform: 9.20966 Iteration(f): 3 -- diff. to prev. transform: 6.22883 Iteration(f): 4 -- diff. to prev. transform: 8.12577 Iteration(f): 5 -- diff. to prev. transform: 6.11784 max it: 5 reached! Resolution: 0 S( 38 43 61 ) T( 38 43 61 ) Iteration(f): 1 -- diff. to prev. transform: 5.83495 Iteration(f): 2 -- diff. to prev. transform: 1.34307 Iteration(f): 3 -- diff. to prev. transform: 0.589867 Iteration(f): 4 -- diff. to prev. transform: 0.289573 Iteration(f): 5 -- diff. to prev. transform: 0.137676 max it: 5 reached! - final transform: Tf = [ ... 0.9980802661280 -0.0059694736544 0.0616453384301 -1.7131111872539 -0.0239991870640 0.8803011391816 0.4738079182283 -13.5066607583463 -0.0570948455303 -0.4743777711274 0.8784679327523 13.0909553444701 0 0 0 1.0000000000000 ] - final iscale: If = 1 ********************************************************** * * WARNING: Registration did not converge in 5 steps! * Problem might be ill posed. * Please inspect output manually! * ********************************************************** Final Transform: Adjusting final transform due to initial resampling (voxel or size changes) ... M = [ ... 0.2495200665320 0.0154113346075 0.0014923684136 0.7292410424572 -0.0059997967660 0.1184519795571 -0.2200752847954 16.2081470043947 -0.0142737113826 0.2196169831881 0.1185944427819 -4.6804480513511 0 0 0 1.0000000000000 ] Determinant : 0.015625 writing output transformation to trash.lta ... converting VOX to RAS and saving RAS2RAS... mapmovhdr: Changing vox2ras MOV header (to map to DST) ... To check aligned result, run: freeview -v /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… imageDump_coregistered.mgz Registration took 0 minutes and 1 seconds. Thank you for using RobustRegister! If you find it useful and use it for a publication, please cite: Highly Accurate Inverse Consistent Registration: A Robust Approach M. Reuter, H.D. Rosas, B. Fischl. NeuroImage 53(4):1181-1196, 2010. http://dx.doi.org/10.1016/j.neuroimage.2010.07.020 http://reuter.mit.edu/papers/reuter-robreg10.pdf $Id: mri_robust_register.cpp,v 1.77 2016/01/20 23:36:17 greve Exp $ --mov: Using imageDump.mgz as movable/source volume. --dst: Using /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… as target volume. --lta: Output transform as trash.lta . --mapmovhdr: Will save header adjusted movable as imageDump_coregistered.mgz ! --affine: Enableing affine transform! --sat: Using saturation 50 in M-estimator! reading source 'imageDump.mgz'... reading target '/mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/…'. .. Registration::setSourceAndTarget(MRI s, MRI t, keeptype = TRUE ) Type Source : 4 Type Target : 3 ensure both FLOAT (3) Reordering axes in mov to better fit dst... ( 1 3 -2 ) MRIreorder() ----------- xdim=1 ydim=3 zdim=-2 src 131 241 99, 0.250000 0.250000 0.250000 dst 131 99 241, 0.250000 0.250000 0.250000 Determinant after swap : 0.015625 Mov: (0.25, 0.25, 0.25)mm and dim (131, 99, 241) Dst: (1, 1, 1)mm and dim (38, 43, 57) Asserting both images: 1mm isotropic - reslicing Mov ... -- changing data type from 4 to 3 (noscale = 0)... -- Original : (0.25, 0.25, 0.25)mm and (131, 99, 241) voxels. -- Resampled: (1, 1, 1)mm and (38, 43, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 - reslicing Dst ... -- Original : (1, 1, 1)mm and (38, 43, 57) voxels. -- Resampled: (1, 1, 1)mm and (38, 43, 61) voxels. -- Reslicing using cubic bspline MRItoBSpline degree 3 Registration::computeMultiresRegistration - computing centroids - computing initial transform -- using translation info - Get Gaussian Pyramid Limits ( min size: 16 max size: -1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - Build Gaussian Pyramid ( Limits min steps: 0 max steps: 1 ) - initial transform: Ti = [ ... 1.0000000000000 0 0 0.1781175809123 0 1.0000000000000 0 1.0539986543476 0 0 1.0000000000000 -3.1974083471847 0 0 0 1.0000000000000 ] - initial iscale: Ii =1 Resolution: 1 S( 19 21 30 ) T( 19 21 30 ) Iteration(f): 1 -- diff. to prev. transform: 9.84742 Iteration(f): 2 -- diff. to prev. transform: 7.72517 Iteration(f): 3 -- diff. to prev. transform: 8.94618 Iteration(f): 4 -- diff. to prev. transform: 7.30294 Iteration(f): 5 -- diff. to prev. transform: 5.69484 max it: 5 reached! Resolution: 0 S( 38 43 61 ) T( 38 43 61 ) Iteration(f): 1 -- diff. to prev. transform: 11.7013 Iteration(f): 2 -- diff. to prev. transform: 3.26787 Iteration(f): 3 -- diff. to prev. transform: 1.06278 Iteration(f): 4 -- diff. to prev. transform: 0.347277 Iteration(f): 5 -- diff. to prev. transform: 0.0826464 max it: 5 reached! - final transform: Tf = [ ... 1.1636664104160 -0.3014738824441 0.0004403516595 4.0520187720971 -0.0480158583329 1.0596278475093 0.4954259490783 -17.9010148715481 -0.2453688431946 -0.4779665918288 0.8802303084621 16.7816318160186 0 0 0 1.0000000000000 ] - final iscale: If = 1 ********************************************************** * * WARNING: Registration did not converge in 5 steps! * Problem might be ill posed. * Please inspect output manually! * ********************************************************** Final Transform: Adjusting final transform due to initial resampling (voxel or size changes) ... M = [ ... 0.2909164812245 0.0001100842157 0.0753684565922 -3.0302464159984 -0.0120039592287 0.1238564808785 -0.2649069144859 17.7887142169889 -0.0613421845898 0.2200575304725 0.1194916267047 -1.6040021052477 0 0 0 1.0000000000000 ] Determinant : 0.0216399 Decompose into Rot * Shear * Scale : Rot = [ ... 0.9808313831675 0.1119800663090 0.1594686882846 0.0897438323260 0.4668219029177 -0.8797859714247 -0.1729619679387 0.8772330224665 0.4478240524369 ] Shear = [ ... 1.0000000000000 -0.1069794540990 0.0987385001868 -0.0910164402411 1.0000000000000 -0.0348388469911 0.0999837864599 -0.0414655431721 1.0000000000000 ] Scale = diag([ 0.2948725983257 0.2508729779031 0.2985915205121 ]) writing output transformation to trash.lta ... converting VOX to RAS and saving RAS2RAS... mapmovhdr: Changing vox2ras MOV header (to map to DST) ... To check aligned result, run: freeview -v /mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… imageDump_coregistered.mgz Registration took 0 minutes and 1 seconds. Thank you for using RobustRegister! If you find it useful and use it for a publication, please cite: Highly Accurate Inverse Consistent Registration: A Robust Approach M. Reuter, H.D. Rosas, B. Fischl. NeuroImage 53(4):1181-1196, 2010. http://dx.doi.org/10.1016/j.neuroimage.2010.07.020 http://reuter.mit.edu/papers/reuter-robreg10.pdf Reading contexts of file /usr/local/packages/freesurfer_v6.0.0/average/HippoSF/atlas/compressionLookupTable.txt Constructing image-to-world transform from header information (asegMod.mgz) Returning the following transform: AffineTransform (0x2b82ee48f820) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 422 Debug: Off Object Name: Observers: none Matrix: -1 -1.86265e-09 1.3024e-09 -3.49428e-09 -1.16415e-10 1 1.86265e-09 -1 -1.16415e-10 Offset: [132.04, -111.801, 144.75] Center: [0, 0, 0] Translation: [132.04, -111.801, 144.75] Inverse: -1 1.3024e-09 1.86265e-09 -1.86265e-09 -1.16415e-10 -1 -3.49428e-09 1 -1.16415e-10 Singular: 0 Constructing image-to-world transform from header information (/mnt/BIAC/.users/ch186/ duhsnas-pri.dhe.duke.edu/dusom_morey/Data/Lab/PGC/T1s/Duke_data/Freesurfer/… ) Returning the following transform: AffineTransform (0x2b82ee48f820) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 579 Debug: Off Object Name: Observers: none Matrix: -0.290916 -0.000110086 -0.0753684 -0.0613422 0.220058 0.119492 0.012004 -0.123856 0.264907 Offset: [49.0706, -22.4049, 0.96176] Center: [0, 0, 0] Translation: [49.0706, -22.4049, 0.96176] Inverse: -3.37777 -0.432721 -0.765819 -0.81721 3.51948 -1.82003 -0.229025 1.66513 2.95866 Singular: 0 Transform before cropping: AffineTransform (0x2b82ee48f820) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 581 Debug: Off Object Name: Observers: none Matrix: 0.290916 0.000110086 0.0753685 -0.012004 0.123856 -0.264907 -0.0613422 0.220058 0.119492 Offset: [82.9698, 143.789, 89.396] Center: [0, 0, 0] Translation: [82.9698, 143.789, 89.396] Inverse: 3.37777 0.765819 -0.432721 0.81721 1.82003 3.51948 0.229025 -2.95866 1.66513 Singular: 0 WorldToImageTransform before cropping: AffineTransform (0x2b82ec807bf0) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 583 Debug: Off Object Name: Observers: none Matrix: -1 1.3024e-09 1.86265e-09 -1.86265e-09 -1.16415e-10 -1 -3.49428e-09 1 -1.16415e-10 Offset: [132.04, 144.75, 111.801] Center: [0, 0, 0] Translation: [132.04, 144.75, 111.801] Inverse: -1 -1.86265e-09 1.3024e-09 -3.49428e-09 -1.16415e-10 1 1.86265e-09 -1 -1.16415e-10 Singular: 0 m_BoundingBoxSize: [131, 241,99] minimalMappedCoordinate: [82.9698, 116.267,81.4215] maximalMappedCoordinate: [128.201, 173.514,153.92] Cropping with min [78 111 74] and max [133 179 161] m_OriginalImageRegion before checking margins: ImageRegion (0x2b82ec809218) Dimension: 3 Index: [78, 111, 74] Size: [56, 69, 88] m_CroppedImageRegion before checking margins: ImageRegion (0x2b82ec8091e0) Dimension: 3 Index: [0, 0, 0] Size: [56, 69, 88] m_OriginalImageRegion after checking margins: ImageRegion (0x2b82ec809218) Dimension: 3 Index: [78, 111, 74] Size: [56, 69, 88] m_CroppedImageRegion after checking margins: ImageRegion (0x2b82ec8091e0) Dimension: 3 Index: [0, 0, 0] Size: [56, 69, 88] Transform after cropping: AffineTransform (0x2b82ee48f820) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 740 Debug: Off Object Name: Observers: none Matrix: 0.290916 0.000110086 0.0753685 -0.012004 0.123856 -0.264907 -0.0613422 0.220058 0.119492 Offset: [4.96976, 32.7887, 15.396] Center: [0, 0, 0] Translation: [4.96976, 32.7887, 15.396] Inverse: 3.37777 0.765819 -0.432721 0.81721 1.82003 3.51948 0.229025 -2.95866 1.66513 Singular: 0 WorldToImageTransform after cropping: AffineTransform (0x2b82ec807bf0) RTTI typeinfo: itk::AffineTransform<double, 3u> Reference Count: 1 Modified Time: 741 Debug: Off Object Name: Observers: none Matrix: -1 1.3024e-09 1.86265e-09 -1.86265e-09 -1.16415e-10 -1 -3.49428e-09 1 -1.16415e-10 Offset: [54.0404, 33.7505, 37.8009] Center: [0, 0, 0] Translation: [54.0404, 33.7505, 37.8009] Inverse: -1 -1.86265e-09 1.3024e-09 -3.49428e-09 -1.16415e-10 1 1.86265e-09 -1 -1.16415e-10 Singular: 0 Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Transforming points Warning: This concatenation operation includes an empty array with an incorrect number of rows. Concatenation including empty arrays will require all arrays to have the same number of rows in a future release. [ > In segmentSubjectT1_autoEstimateAlveusML at 325] Reading contexts of file /usr/local/packages/freesurfer_v6.0.0/average/HippoSF/atlas/compressionLookupTable.txt -------------- Making Lateral-nucleus map to reduced label 1 Making Paralaminar-nucleus map to reduced label 1 Making Basal-nucleus map to reduced label 1 Making Accessory-Basal-nucleus map to reduced label 1 Making Corticoamygdaloid-transitio map to reduced label 1 Making Central-nucleus map to reduced label 1 Making Cortical-nucleus map to reduced label 1 Making Medial-nucleus map to reduced label 1 Making Anterior-amygdaloid-area-AAA map to reduced label 1 -------------- Making alveus map to reduced label 2 Making Hippocampal_tail map to reduced label 2 Making HATA map to reduced label 2 Making fimbria map to reduced label 2 Making parasubiculum map to reduced label 2 Making hippocampal-fissure map to reduced label 2 -------------- Making Left-Cerebral-Cortex map to reduced label 3 -------------- Making Left-Cerebral-White-Matter map to reduced label 4 -------------- Making Left-Lateral-Ventricle map to reduced label 5 -------------- Making Left-choroid-plexus map to reduced label 6 -------------- Making Unknown map to reduced label 7 -------------- Making Left-VentralDC map to reduced label 8 -------------- Making Left-Putamen map to reduced label 9 -------------- Making Left-Pallidum map to reduced label 10 -------------- Making Left-Thalamus-Proper map to reduced label 11 -------------- Making Left-Accumbens-area map to reduced label 12 -------------- Making Left-Caudate map to reduced label 13 Error using segmentSubjectT1_autoEstimateAlveusML (line 348) The vector of prior probabilities in the mesh nodes must always sum to one over all classes

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Re: [Freesurfer] mri_glmfit-sim using --cwp 0.05, --cwp 0.1, --cwp 0.999
by Douglas N. Greve 09 Sep '20

09 Sep '20

0.09940 and 0.10338 seem pretty close to me:). The summary file has Hi and Low which is the 95% confidence interval assuming a binomial model at the mean prob On 9/9/2020 3:24 PM, freesurferlist(a)gmx.com wrote: > External Email - Use Caution > > Thanks, I was looking for the higher resolution as, from my understanding, the p-value of a cluster is usually reported as “p =“ rather than “p <“ (but this may be not worth the extra computational time for cluster 1). > > Just as a follow up question, what about cluster 2 for cwp0.1 and cwp0.999. This has a CWP of 0.09940 and 0.10338 respectively. Should we be expecting convergence by 10,000 iterations for this cluster? > > > > On 10/9/20 at 12:18 am, Douglas N. Greve wrote: > > The issue is that the chance of this event happening by chance is very > low, around 2-14 times out of 10,000. You are getting this variation > because you are only using 10000 iterations. But why would you need > higher resolution to your p-value? It will definitely be below 0.05 > needed for publication. > > On 9/8/2020 8:45 PM, Paul wrote: >> External Email - Use Caution >> >> Dear Douglas, >> Thanks for looking in this. Please see files attached. >> Also, I have used Freesurfer 5.1 for all the processing (i.e recon-all >> and editing etc) and have used Freesurfer 6.0 for the statistical >> analysis (i.e. mris_preproc, mri_surf2surf, mri_glmfit) and the patch >> version of mri_glmfit-sim (i.e >> ftp://surfer.nmr.mgh.harvard.edu/pub/dist/freesurfer/6.0.0-patch/mri_glmfit…) >> <ftp://surfer.nmr.mgh.harvard.edu/pub/dist/freesurfer/6.0.0-patch/mri_glmfit…> >> Kind regards, >> Paul >> *Sent:* Wednesday, September 09, 2020 at 1:01 AM >> *From:* "Douglas N. Greve" <dgreve(a)mgh.harvard.edu> >> *To:* freesurfer(a)nmr.mgh.harvard.edu >> *Subject:* Re: [Freesurfer] mri_glmfit-sim using --cwp 0.05, --cwp >> 0.1, --cwp 0.999 >> On 9/7/2020 10:52 PM, Paul wrote: >> >> External Email - Use Caution >> >> Dear Freesurfer Experts, >> I have few questions regarding CWP values from mri_glmfit-sim >> using --cwp 0.05, --cwp 0.1, --cwp 0.999. >> Using the 3 three commands below (A, B and C): >> A. mri_glmfit-sim --glmdir lh_status.glmdir --perm 10000 1.3 abs >> --cwp 0.05 --2spaces --bg 1 >> B. mri_glmfit-sim --glmdir lh_status.glmdir --perm 10000 1.3 abs >> --cwp 0.1 --2spaces --bg 1 >> C. mri_glmfit-sim --glmdir lh_status.glmdir --perm 10000 1.3 abs >> --cwp 0.999 --2spaces --bg 1 >> I end up with the same significant ClusterNo 1. (in terms of Max, >> VtxMax, Size(mm^2), MNIX, MNIY, MNIZ, NVtxs, WghtVtx, Annot) >> However, the CWP is 0.00040, 0.00140, and 0.00020 for A, B and C >> respetively. >> I was expected after 10,000 iterations, the CWP would be more >> closely matched or even convergent. >> Could you please let me know if this result is typical after >> 10,000 iterations? >> Also, should I be using more iterations (say 20k or more 100k?) to >> reach convergence across A, B, and C or is it usual to just report >> A, B or C? >> >> I don't understand. All you are changing is the CWP threshold? The >> final CWP value for a cluster should not be changing at all. If this >> is the case, can you send me the summary file for each? >> >> Kind regards, >> Paul >> >> _______________________________________________ >> Freesurfer mailing list >> Freesurfer(a)nmr.mgh.harvard.edu >> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer >> >> >> _______________________________________________ Freesurfer mailing >> list Freesurfer(a)nmr.mgh.harvard.edu >> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer > The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Mass General Brigham Compliance HelpLine at http://www.massgeneralbrigham.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. >

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Freesurfer September 2020