External Email - Use Caution
Dear Freesurfer expert,
I hope this email finds you well. I am currently working on a project
involving FreeSurfer's cluster-wise correction methods, and I encountered
an unexpected result when adjusting the Cluster-Forming Threshold (CFT) and
Cluster-Wise Probability (CWP) values. I would greatly appreciate your
expertise on this matter.
In my analysis, I observed that some regions were not detected when using a
CFT of 1.3 and a CWP of 0.05. However, these regions emerged as significant
when I increased the CFT to 2.0 while keeping the CWP constant at 0.05.
This finding appears counterintuitive, as a higher CFT typically results in
fewer clusters being detected due to the increased threshold for
significance.
Could you please help clarify why this phenomenon might occur? Specifically:
1. How might the higher CFT (2.0) interact with the CWP (0.05) to reveal
regions that did not appear with a lower CFT (1.3)?
2. Is it possible that the increase in CFT reduces noise or increases
signal clarity in such a way that previously undetected clusters reach
significance?
Thank you very much for your time and guidance. I look forward to any
insights you can provide on this topic.
Jonghun Lee
Master's Student, Advanced Image Processing Technology Lab
Yonsei University
