Dear experts,
I am studying a group of patients with a genetic illness that implies
alterations of olfactory tracts and sulci. My aim was to explore the depth
of the olfactory sulci in both patients and controls.
I draw a ROI following the image of the sulcus in the fsaverage (see the
figure) and I extracted measures of 'sulc' and 'thickness' for any subject
using this ROI.
My problem is that I found only zero or negative values for sulc (also in
controls!). This means that there is not a sulcus, but a gyrus? The
difference is statistically significant between patients (more negative)
and controls (around zero or low negative).
What is the problem and how can I measure the depth of the sulcus? Perhaps
should I work on an 'average' surface based on my healthy controls? How
can I obtain it?
Thank you for any help!
Angela